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Methotrexate disodium

Name: Methotrexate disodium
Brand: TargetMol
SKU: T8003
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T8003Cas No. 7413-34-5

Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor

Methotrexate disodium

🥰Excellent

Purity: 99.96%

Catalog No. T8003Cas No. 7413-34-5

Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor

Pack Size	Price	Availability
50 mg	$34	In Stock
100 mg	$48	In Stock
200 mg	$63	In Stock
500 mg	$128	In Stock

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Batch Information

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Purity:99.96%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description

Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor

Chemical Properties

Molecular Weight	498.4
Formula	C₂₀H₂₀N₈Na₂O₅
Cas No.	7413-34-5
Smiles	[Na+].[Na+].CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: Slightly soluble

H2O: 40 mg/mL (80.26 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.0064 mL	10.0321 mL	20.0642 mL	100.3210 mL
5 mM	0.4013 mL	2.0064 mL	4.0128 mL	20.0642 mL
10 mM	0.2006 mL	1.0032 mL	2.0064 mL	10.0321 mL
20 mM	0.1003 mL	0.5016 mL	1.0032 mL	5.0161 mL
50 mM	0.0401 mL	0.2006 mL	0.4013 mL	2.0064 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc