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Anti-Integrin alpha 1 Polyclonal Antibody
(Synonyms: VLA1., VLA-1, Very late activation protein 1, Laminin and collagen receptor, ITGA1, Itga 1, ITA1, Integrin alpha-1, CD49a antigen, CD49a, CD49 antigen-like family member A, CD 49a) Copy Product Info
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Synonyms: VLA1., VLA-1, Very late activation protein 1, Laminin and collagen receptor, ITGA1, Itga 1, ITA1, Integrin alpha-1, CD49a antigen, CD49a, CD49 antigen-like family member A, CD 49a
Catalog No. TMAB-00978 Copy Product Info
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Anti-Integrin alpha 1 Polyclonal Antibody is a Rabbit antibody targeting Integrin alpha 1. Anti-Integrin alpha 1 Polyclonal Antibody can be used in WB.
Anti-Integrin alpha 1 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
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| Description | Anti-Integrin alpha 1 Polyclonal Antibody is a Rabbit antibody targeting Integrin alpha 1. Anti-Integrin alpha 1 Polyclonal Antibody can be used in WB. |
| Synonyms | VLA1., VLA-1, Very late activation protein 1, Laminin and collagen receptor, ITGA1, Itga 1, ITA1, Integrin alpha-1, CD49a antigen, CD49a, CD49 antigen-like family member A, CD 49a |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Rat,Cow,Horse) |
| Application | |
| Recommended Dose | WB=1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Membrane; Single-pass type I membrane protein. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | Integrins are important extracellular matrix (ECM) receptor proteins located on cell surfaces. They are hetrodimers composed of an alpha and a beta transmembrane glycoprotein subunit. Around twenty two different integrins (different alpha/ beta subunit combinations) are found in nature. Integrins are generally present in high concentrations at the cell surface, but, unlike most other cell surface receptors, they bind ligands with very low affinity. Due to their weak individual binding, integrins need to cluster and bind in groups in order to effectively bind the ECM. Integrins bind many different ligands including laminin. Each integrin is made up of a large N terminal extracellular domain that binds the ECM ligand and a small C terminal cytoplasmic domain that mediates interaction with the actin cytoskeleton and signaling function. Alpha 1 integrin along with alpha 2, alpha L and alpha M has a unique inserted domain. Integrin alpha 1 is a receptor for laminin and collagen. The alpha1 subunit is also known as CD49a. CD49a associates with CD29 (beta 1 integrin), to form an alpha1 beta1 heterodimer, identified as the rat homologue to VLA1, which is involved in cellular adhesion to laminin and collagen. |
| Immunogen | KLH conjugated synthetic peptide: human Integrin alpha 1 |
| Antigen Species | Human |
| Gene Name | ITGA1 |
| Gene ID | |
| Protein Name | Integrin alpha-1 |
| Uniprot ID | |
| Biology Area | Basal Lamina,Alpha,Surface Molecules |
| Function | Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. |
| Molecular Weight | Theoretical: 128 kDa. Actual: 160 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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