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KAN0438757

Name: KAN0438757
Brand: TargetMol
SKU: T11741
Price: 103 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11741Cas No. 1451255-59-6

KAN0438757 is a selective and potent inhibitor of the metabolic kinase [PFKFB3] with an IC50 of 0.19 μM.

KAN0438757

🥰Excellent

Purity: 99.34%

Catalog No. T11741Cas No. 1451255-59-6

KAN0438757 is a selective and potent inhibitor of the metabolic kinase [PFKFB3] with an IC50 of 0.19 μM.

Pack Size	Price	Availability
1 mg	$103	In Stock
5 mg	$202	In Stock
10 mg	$323	In Stock
25 mg	$583	In Stock
50 mg	$801	In Stock
100 mg	$1,090	In Stock
1 mL x 10 mM (in DMSO)	$217	In Stock

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Batch Information

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Purity:99.34%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	KAN0438757 is a selective and potent inhibitor of the metabolic kinase [PFKFB3] with an IC50 of 0.19 μM.
Targets&IC50	PFKFB3:0.19 μM

Chemical Properties

Molecular Weight	447.43
Formula	C₂₁H₁₈FNO₇S
Cas No.	1451255-59-6
Smiles	OCCOC(=O)c1ccc(NS(=O)(=O)c2cccc(c2)-c2cc(F)ccc2O)cc1O
Relative Density.	1.507 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 130 mg/mL (290.55 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2350 mL	11.1749 mL	22.3499 mL	111.7493 mL
5 mM	0.4470 mL	2.2350 mL	4.4700 mL	22.3499 mL
10 mM	0.2235 mL	1.1175 mL	2.2350 mL	11.1749 mL
20 mM	0.1117 mL	0.5587 mL	1.1175 mL	5.5875 mL
50 mM	0.0447 mL	0.2235 mL	0.4470 mL	2.2350 mL
100 mM	0.0223 mL	0.1117 mL	0.2235 mL	1.1175 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc