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KAN0438757

Name: KAN0438757
Brand: TargetMol
SKU: T11741
Price: 103 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11741Cas No. 1451255-59-6

KAN0438757 is a selective and potent inhibitor of the metabolic kinase [PFKFB3] with an IC50 of 0.19 μM.

KAN0438757

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Purity: 99.34%

Catalog No. T11741Cas No. 1451255-59-6

KAN0438757 is a selective and potent inhibitor of the metabolic kinase [PFKFB3] with an IC50 of 0.19 μM.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$103	In Stock	In Stock
5 mg	$202	In Stock	In Stock
10 mg	$323	In Stock	In Stock
25 mg	$583	In Stock	In Stock
50 mg	$801	In Stock	In Stock
100 mg	$1,090	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$217	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.34%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

KAN0438757 AI Summary

KAN0438757 exhibits bioactivity as an inhibitor of PFKFB3 in human NUGC-3, MIA PaCa-2, and PANC-1 cells, resulting in decreased production of Fructose-2,6-Bisphosphate with an IC50 value of 90.0 nM across these cell lines..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	KAN0438757 is a selective and potent inhibitor of the metabolic kinase [PFKFB3] with an IC50 of 0.19 μM.
Targets&IC50	PFKFB3:0.19 μM

Chemical Properties

Molecular Weight	447.43
Formula	C₂₁H₁₈FNO₇S
Cas No.	1451255-59-6
Smiles	OCCOC(=O)c1ccc(NS(=O)(=O)c2cccc(c2)-c2cc(F)ccc2O)cc1O
Relative Density.	1.507 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 130 mg/mL (290.55 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.38 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2350 mL	11.1749 mL	22.3499 mL	111.7493 mL
5 mM	0.4470 mL	2.2350 mL	4.4700 mL	22.3499 mL
10 mM	0.2235 mL	1.1175 mL	2.2350 mL	11.1749 mL
20 mM	0.1117 mL	0.5587 mL	1.1175 mL	5.5875 mL
50 mM	0.0447 mL	0.2235 mL	0.4470 mL	2.2350 mL
100 mM	0.0223 mL	0.1117 mL	0.2235 mL	1.1175 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc