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icFSP1

Name: icFSP1
Brand: TargetMol
SKU: T77344
Price: 290 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T77344Cas No. 1115910-36-5

icFSP1 is a mitochondria-associated apoptosis-inducing factor regulator with antitumor activity for the study and treatment of tumor diseases.

icFSP1

🥰Excellent

Purity: 99.93%

Catalog No. T77344Cas No. 1115910-36-5

icFSP1 is a mitochondria-associated apoptosis-inducing factor regulator with antitumor activity for the study and treatment of tumor diseases.

Pack Size	Price	Availability
1 mg	$290	In Stock
5 mg	$664	In Stock
10 mg	$930	In Stock
25 mg	$1,310	In Stock
50 mg	$1,640	In Stock
100 mg	$1,995	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.93%

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COA LCMS HNMR LCMS

Product Introduction

Bioactivity

Description	icFSP1 is a mitochondria-associated apoptosis-inducing factor regulator with antitumor activity for the study and treatment of tumor diseases.
In vitro	icFSP1(5 µM) triggers subcellular relocalization of FSP1 from the membrane and FSP1 condensation before ferroptosis induction, in synergism with GPX4 inhibition[1].
In vivo	In a tumour-bearing mouse model, icFSP1(i.p.) significantly inhibited tumour growth and decreased tumour weight, without affecting body weight. icFSP1 markedly increased the abundance of hFSP1 condensates and immunoreactivity to 4-hydroxynonenal, a lipid peroxidation breakdown product[1].

Chemical Properties

Molecular Weight	459.49
Formula	C₂₆H₂₅N₃O₅
Cas No.	1115910-36-5
Smiles	O=C1N(C(C)=NC=2C1=CC=CC2)C3=CC=C(NC(CC4=CC(OC)=C(OC)C(OC)=C4)=O)C=C3
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (119.7 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1763 mL	10.8816 mL	21.7633 mL	108.8163 mL
5 mM	0.4353 mL	2.1763 mL	4.3527 mL	21.7633 mL
10 mM	0.2176 mL	1.0882 mL	2.1763 mL	10.8816 mL
20 mM	0.1088 mL	0.5441 mL	1.0882 mL	5.4408 mL
50 mM	0.0435 mL	0.2176 mL	0.4353 mL	2.1763 mL
100 mM	0.0218 mL	0.1088 mL	0.2176 mL	1.0882 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc