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Tirzepatide sodium salt

Catalog No. TP1111L1

Synonyms: LY-3298176 sodium salt, Tirzepatide sodium salt（2023788-19-2 free base）

Tirzepatide sodium salt (LY3298176 sodium salt) is a GIP and GLP-1 receptor agonist with neuroprotective activity and can be used to treat obesity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Tirzepatide sodium salt Chemical Structure

Tirzepatide sodium salt, CAS N/A

Pack Size	Availability	Price/USD
1 mg	In stock	$ 263.00
5 mg	In stock	$ 689.00
10 mg	In stock	$ 1,130.00
25 mg	In stock	$ 1,690.00
50 mg	In stock	$ 2,320.00
100 mg	In stock	$ 3,130.00

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Purity: 99.69%

Biological Description

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Description	Tirzepatide sodium salt (LY3298176 sodium salt) is a GIP and GLP-1 receptor agonist with neuroprotective activity and can be used to treat obesity.
In vitro	Under high glucose-induced conditions, treatment of SHSY5Y cells with Tirzepatide sodium salt at concentrations ranging from 0 to 0.4 μM for 7 days resulted in significant upregulation of CREB and BDNF mRNA expression. Additionally, it increased the protein levels of pAkt, MAP2, GAP43, AGBL4, GLUT4, SORBS1, and Bcl-2 while decreasing the protein level of BAX[1].
In vivo	In diet-induced obese (DIO) mice, Tirzepatide sodium salt (10 nM/kg, subcutaneous injection) reduced body weight and food consumption. It decreased glucose, insulin, leptin, and C-peptide levels[2].

Synonyms	LY-3298176 sodium salt, Tirzepatide sodium salt（2023788-19-2 free base）
Molecular Weight	N/A

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Fontanella RA, et al. Tirzepatide prevents neurodegeneration through multiple molecular pathways. J Transl Med. 2024 Jan 29;22(1):114. 2. Huang L, et al. Tirzepatide inhibits tumor growth in mice with diet-induced obesity. bioRxiv, 2023: 2023.06. 22.546093. 3. Guo X, et al. Tirzepatide ameliorates spatial learning and memory impairment through modulation of aberrant insulin resistance and inflammation response in diabetic rats. Front Pharmacol. 2023 Aug 28;14:1146960.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Tirzepatide sodium salt GPCR/G Protein Glucagon Receptor LY-3298176 sodium salt Tirzepatide sodium salt（2023788-19-2 free base） inhibitor inhibit

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