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Anti-Alpha-Synuclein Polyclonal Antibody
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Catalog No. TMAB-00107
Alias α-synuclein, Snca, Non-A4 component of amyloid precursor, Non-A β component of AD amyloid, Non-A beta component of AD amyloid, NACP, Alpha-synuclein
Anti-Alpha-Synuclein Polyclonal Antibody is a Rabbit antibody targeting Alpha-Synuclein. Anti-Alpha-Synuclein Polyclonal Antibody can be used in WB.
Anti-Alpha-Synuclein Polyclonal Antibody
Anti-Alpha-Synuclein Polyclonal Antibody
😃Good
Catalog No. TMAB-00107Alias α-synuclein, Snca, Non-A4 component of amyloid precursor, Non-A β component of AD amyloid, Non-A beta component of AD amyloid, NACP, Alpha-synuclein
Anti-Alpha-Synuclein Polyclonal Antibody is a Rabbit antibody targeting Alpha-Synuclein. Anti-Alpha-Synuclein Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Alpha-Synuclein Polyclonal Antibody is a Rabbit antibody targeting Alpha-Synuclein. Anti-Alpha-Synuclein Polyclonal Antibody can be used in WB. |
| Synonyms | α-synuclein, Snca, Non-A4 component of amyloid precursor, Non-A β component of AD amyloid, Non-A beta component of AD amyloid, NACP, Alpha-synuclein |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 25 μg total protein per Lane of various lysates probed with Alpha-Synucleusn polyclonal antibody, unconjugated (TMAB-00107) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at RT for 60 min.  |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Membrane. Nucleus. Cell junction, synapse. Note=Membrane-bound in dopaminergic neurons. |
| Tissue Specificity | Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]. |
| Immunogen | Recombinant Protein: full length Alpha-Synuclein |
| Gene Name | SNCA |
| Protein Name | alpha-synuclein |
| Biology Area | Tangles & Tau,Synuclein |
| Function | May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. |
| Molecular Weight | Theoretical: 14 kDa. |
| Color | Transparent |
| Appearance | Liquid |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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