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Tallimustine HCl

Catalog No. T68151L CAS 118438-45-2

Synonyms: Tallimustine HCl(115308-98-0 Free base)

Tallimustine HCl is a DNA inhibitor, an AT-specific alkylated antitumor derivative of diamycin.Tallimustine HCl can be used in severe combined immunodeficiency mouse models of adult myelogenous leukemia, which can be used for the treatment of leukemia.

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Tallimustine HCl, CAS 118438-45-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 195.00
5 mg	In stock	$ 430.00
10 mg	In stock	$ 636.00
25 mg	In stock	$ 987.00
50 mg	In stock	$ 1,360.00
100 mg	In stock	$ 1,830.00
500 mg	In stock	$ 3,680.00

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Purity: 98.52%

Biological Description

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Description	Tallimustine HCl is a DNA inhibitor, an AT-specific alkylated antitumor derivative of diamycin.Tallimustine HCl can be used in severe combined immunodeficiency mouse models of adult myelogenous leukemia, which can be used for the treatment of leukemia.
Targets&IC50	CEM cells:3.5 nM
In vitro	Tallimustine HCl (0.1-10 μM; 4 h) causes harm to isolated SV40 DNA. Additionally, Tallimustine HCl exhibits cytotoxicity in CEM cells after 72 hours, displaying an IC50 of 3.5 nM.[1] Tallimustine HCl (25 and 100 nM, 6 days) induces erythroid differentiation of K562 cells.[2] Tallimustine HCl (100 nM, 6 days) increases accumulation of γ-globin mRNA in K562 cells.[2] Tallimustine HCl (0.5 μg/mL, 1 h) arrests SW626 cells in G2/M phase.[3]
In vivo	Tallimustine HCl (3 mg/kg; i.p.; ) prolonged survival and shows antileukemic activity in L1210 tumor-bearing mice and.[4]

Synonyms	Tallimustine HCl(115308-98-0 Free base)
Molecular Weight	734.08
Formula	C32H39Cl3N10O4
CAS No.	118438-45-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Herzig MC, et al. Tallimustine lesions in cellular DNA are AT sequence-specific but not region-specific. Biochemistry. 1999;38(42):14045-14055. 2. Bianchi N, et al. Accumulation of gamma-globin mRNA and induction of erythroid differentiation after treatment of human leukaemic K562 cells with tallimustine. Br J Haematol. 2001;113(4):951-961. 3. Erba E, et al. Comparison of cell-cycle phase perturbations induced by the DNA-minor-groove alkylator tallimustine and by melphalan in the SW626 cell line. Int J Cancer. 1995;62(2):170-175. 4. Tagliabue G, et al. Combination of the new minor groove alkylator tallimustine and melphalan. Eur J Cancer. 1997;33(2):284-287.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Bioactive Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max Immunology/Inflammation Compound Library

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Keywords

Tallimustine HCl 118438-45-2 DNA Damage/DNA Repair DNA Tallimustine HCl(115308-98-0 Free base) inhibitor inhibit

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