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Ginsenoside C-K

Name: Ginsenoside C-K
Brand: TargetMol
SKU: T3811
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3811Cas No. 39262-14-1

Alias Ginsenoside K, Ginsenoside compound K

Ginsenoside C-K (Ginsenoside K) is a bacterial metabolite of G-Rb1 exhibiting anti-inflammatory effects by reducing iNOS and COX-2.

Ginsenoside C-K

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Purity: 99.97%

Catalog No. T3811Alias Ginsenoside K, Ginsenoside compound KCas No. 39262-14-1

Ginsenoside C-K (Ginsenoside K) is a bacterial metabolite of G-Rb1 exhibiting anti-inflammatory effects by reducing iNOS and COX-2.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$40	In Stock	In Stock
10 mg	$66	In Stock	In Stock
25 mg	$108	In Stock	In Stock
50 mg	$158	In Stock	In Stock
100 mg	$236	In Stock	In Stock
200 mg	$349	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$56	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.97%

Color:White

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COA LCMS HNMR

Product Introduction

Ginsenoside C-K AI Summary

Ginsenoside C-K exhibits a range of bioactivities and pharmacokinetic properties. It demonstrates inhibition of human recombinant aldose reductase with an IC50 value greater than 200,000 nM. The compound shows moderate permeability across several cell lines, with greater movement from basolateral to apical side, which is influenced by P-gp inhibitors like verapamil and cyclosporine A. In vivo, it has a moderate Tmax, Cmax, and elimination rate with a short half-life in wildtype FVB mice, which is extended in MDR1a/b(-/-) mice, suggesting an impact by efflux transporters; it has low oral bioavailability in rats. In antiviral studies, Ginsenoside C-K exhibits activity against SARS-CoV-2, including 3CL-Pro protease inhibition and a 2.22% inhibition of virus-induced cytotoxicity in Caco-2 cells at 10 µM. However, in VERO-6 cells, it shows varying inhibition levels from -0.01% to 0.71%. The compound also has anti-asthmatic potential, reducing methacholine-induced airway resistance and plasma IgE levels in an ovalbumin-induced asthmatic BALB/c mouse model. Furthermore, it has demonstrated hepatoprotective effects against D-GaIN/CCl4 induced liver injury in mice, reducing GPT levels significantly at a dose of 30 µg/kg. However, it shows negligible to negative activity against human HDAC6. Overall, Ginsenoside C-K has diverse biological activities with potential applications in antiviral, anti-asthmatic, and hepatoprotective therapies, although its permeability and susceptibility to efflux mechanisms pose challenges for its bioavailability and therapeutic efficacy..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ginsenoside C-K (Ginsenoside K) is a bacterial metabolite of G-Rb1 exhibiting anti-inflammatory effects by reducing iNOS and COX-2.
Targets&IC50	CYP2C9:32.0±3.6 μM, CYP2A6:63.6±4.2 μM
Synonyms	Ginsenoside K, Ginsenoside compound K

Chemical Properties

Molecular Weight	622.87
Formula	C₃₆H₆₂O₈
Cas No.	39262-14-1
Smiles	CC(C)=CCC[C@](C)(O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@H]1CC[C@]2(C)[C@@H]1[C@H](O)C[C@@H]1[C@@]3(C)CC[C@H](O)C(C)(C)[C@@H]3CC[C@@]21C
Relative Density.	1.19

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (401.37 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.21 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6055 mL	8.0274 mL	16.0547 mL	80.2736 mL
5 mM	0.3211 mL	1.6055 mL	3.2109 mL	16.0547 mL
10 mM	0.1605 mL	0.8027 mL	1.6055 mL	8.0274 mL
20 mM	0.0803 mL	0.4014 mL	0.8027 mL	4.0137 mL
50 mM	0.0321 mL	0.1605 mL	0.3211 mL	1.6055 mL
100 mM	0.0161 mL	0.0803 mL	0.1605 mL	0.8027 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc