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(R)-ADX-47273

Name: (R)-ADX-47273
Brand: TargetMol
SKU: T13441
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13441Cas No. 851881-59-9

(R)-ADX-47273 is a potent positive allosteric modulator of mGluR5, with an EC50 of 168 nM for potentiation.

(R)-ADX-47273

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Purity: 99.87%

Catalog No. T13441Cas No. 851881-59-9

(R)-ADX-47273 is a potent positive allosteric modulator of mGluR5, with an EC50 of 168 nM for potentiation.

Pack Size	Price	Availability
2 mg	$35	In Stock
5 mg	$59	In Stock
10 mg	$95	In Stock
25 mg	$173	In Stock
50 mg	$273	In Stock
100 mg	$412	In Stock
200 mg	$573	In Stock
1 mL x 10 mM (in DMSO)	$65	In Stock

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Batch Information

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Purity:99.87%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	(R)-ADX-47273 is a potent positive allosteric modulator of mGluR5, with an EC50 of 168 nM for potentiation.
Targets&IC50	mGlu5:168 nM (EC50)

Chemical Properties

Molecular Weight	369.36
Formula	C₂₀H₁₇F₂N₃O₂
Cas No.	851881-59-9
Smiles	Fc1ccc(cc1)C(=O)N1CCC[C@H](C1)c1nc(no1)-c1ccc(F)cc1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (257.2 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7074 mL	13.5369 mL	27.0739 mL	135.3693 mL
5 mM	0.5415 mL	2.7074 mL	5.4148 mL	27.0739 mL
10 mM	0.2707 mL	1.3537 mL	2.7074 mL	13.5369 mL
20 mM	0.1354 mL	0.6768 mL	1.3537 mL	6.7685 mL
50 mM	0.0541 mL	0.2707 mL	0.5415 mL	2.7074 mL
100 mM	0.0271 mL	0.1354 mL	0.2707 mL	1.3537 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc