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Melinamide
🥰Excellent
Catalog No. T16036Cas No. 14417-88-0
Alias DL-N-(α-Methylbenzyl)linoleamide
Melinamide is an antilipidemic compound with pharmacological properties similar to gemfibrozil. Melinamide reduces elevated serum lipids primarily by lowering the triglyceride-rich very low-density lipoprotein (VLDL) fraction. In Type III hyperlipoproteinemia, where cholesterol elevation arises from intermediate-density lipoproteins (IDL), melinamide can decrease serum cholesterol levels.
Melinamide
🥰Excellent
Catalog No. T16036Alias DL-N-(α-Methylbenzyl)linoleamideCas No. 14417-88-0
Melinamide is an antilipidemic compound with pharmacological properties similar to gemfibrozil. Melinamide reduces elevated serum lipids primarily by lowering the triglyceride-rich very low-density lipoprotein (VLDL) fraction. In Type III hyperlipoproteinemia, where cholesterol elevation arises from intermediate-density lipoproteins (IDL), melinamide can decrease serum cholesterol levels.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $95 | - | In Stock | |
| 5 mg | $163 | - | In Stock | |
| 10 mg | $297 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $178 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:＞99.99%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Melinamide is an antilipidemic compound with pharmacological properties similar to gemfibrozil. Melinamide reduces elevated serum lipids primarily by lowering the triglyceride-rich very low-density lipoprotein (VLDL) fraction. In Type III hyperlipoproteinemia, where cholesterol elevation arises from intermediate-density lipoproteins (IDL), melinamide can decrease serum cholesterol levels. |
| Targets&IC50 | Cholesterol:20.9 μM |
| In vitro | D-Melinamide exhibits greater inhibitory efficacy compared to L-Melinamide. It has been observed that DL-Melinamide effectively suppresses acyl CoA: cholesterol acyltransferase (ACAT) activity in mucosal microsomes, achieving 50% inhibition at an approximate concentration of 0.5 μM. Kinetic analysis has revealed that DL-Melinamide acts as an uncompetitive inhibitor against acyl CoA: cholesterol acyltransferase.[2] |
| In vivo | Melinamide induces a substantial decrease in the enhanced intestinal ACAT activity in diabetic rats but does not affect intestinal cholesterol esterase activity. Melinamide is a new hypocholesterolaemic drug. A marked improvement of hypercholesterolaemia in cholesterol-fed diabetic rats occurs concomitantly with the drug treatment.[3] |
| Synonyms | DL-N-(α-Methylbenzyl)linoleamide |
| Molecular Weight | 383.61 |
| Formula | C26H41NO |
| Cas No. | 14417-88-0 |
| Smiles | CCCCC\C=C/C\C=C/CCCCCCCC(=O)NC(C)c1ccccc1 |
| Relative Density. | 0.928 g/cm3 (Predicted) |
| Color | Transparent |
| Appearance | Oil |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 150 mg/mL (391.02 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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