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Glutathione ethyl ester

🥰Excellent
Catalog No. T78616Cas No. 92614-59-0

Glutathione ethyl ester is a cell-permeable, modified form of glutathione (GSH) that undergoes rapid hydrolysis by esterases in vivo to restore GSH levels. It inhibits progression in the early stages of diabetes-associated cataract formation and reduces reactive oxygen species (ROS) content, thereby protecting in vitro mature bovine oocytes from oxidative stress.

Glutathione ethyl ester
Other Forms of Glutathione ethyl ester:

Glutathione ethyl ester

🥰Excellent
Purity: 98.958%
Catalog No. T78616Cas No. 92614-59-0
Glutathione ethyl ester is a cell-permeable, modified form of glutathione (GSH) that undergoes rapid hydrolysis by esterases in vivo to restore GSH levels. It inhibits progression in the early stages of diabetes-associated cataract formation and reduces reactive oxygen species (ROS) content, thereby protecting in vitro mature bovine oocytes from oxidative stress.
Pack SizePriceAvailabilityQuantity
5 mg$40In Stock
10 mg$66In Stock
1 mL x 10 mM (in DMSO)$44In Stock
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Purity:98.958%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
Glutathione ethyl ester is a cell-permeable, modified form of glutathione (GSH) that undergoes rapid hydrolysis by esterases in vivo to restore GSH levels. It inhibits progression in the early stages of diabetes-associated cataract formation and reduces reactive oxygen species (ROS) content, thereby protecting in vitro mature bovine oocytes from oxidative stress.
In vitro
Methods: Glutathione ethyl ester (5 mM) was used to treat bovine oocytes, and the morphology of spindles and chromosomes was observed through immunofluorescence staining.
Results: Glutathione ethyl ester did not significantly improve the normal morphology of spindles, but it significantly reduced the proportion of oocytes with abnormal microtubule configurations after vitrification/warming. [1]
Chemical Properties
Molecular Weight335.38
FormulaC12H21N3O6S
Cas No.92614-59-0
SmilesCCOC(=O)CNC(=O)[C@H](CS)NC(=O)CC[C@H](N)C(O)=O
Relative Density.1.314 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (238.54 mM), Sonication is recommended.
H2O: 80 mg/mL (238.54 mM), Sonication is recommended.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM2.9817 mL14.9085 mL29.8169 mL149.0846 mL
5 mM0.5963 mL2.9817 mL5.9634 mL29.8169 mL
10 mM0.2982 mL1.4908 mL2.9817 mL14.9085 mL
20 mM0.1491 mL0.7454 mL1.4908 mL7.4542 mL
50 mM0.0596 mL0.2982 mL0.5963 mL2.9817 mL
100 mM0.0298 mL0.1491 mL0.2982 mL1.4908 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

ReactiveOxygenSpecies
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