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Glutathione ethyl ester

🥰Excellent
Catalog No. T78616Cas No. 92614-59-0

Glutathione ethyl ester is a cell-permeable, modified form of glutathione (GSH) that undergoes rapid hydrolysis by esterases in vivo to restore GSH levels. It inhibits progression in the early stages of diabetes-associated cataract formation and reduces reactive oxygen species (ROS) content, thereby protecting in vitro mature bovine oocytes from oxidative stress.

Glutathione ethyl ester
Other Forms of Glutathione ethyl ester:

Glutathione ethyl ester

🥰Excellent
Purity: 98.958%
Catalog No. T78616Cas No. 92614-59-0
Glutathione ethyl ester is a cell-permeable, modified form of glutathione (GSH) that undergoes rapid hydrolysis by esterases in vivo to restore GSH levels. It inhibits progression in the early stages of diabetes-associated cataract formation and reduces reactive oxygen species (ROS) content, thereby protecting in vitro mature bovine oocytes from oxidative stress.
Pack SizePriceAvailabilityQuantity
5 mg$40In Stock
10 mgPreferentialIn Stock
25 mgPreferentialIn Stock
1 mL x 10 mM (in DMSO)$44In Stock
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Purity:98.958%
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Product Introduction

Bioactivity
Description
Glutathione ethyl ester is a cell-permeable, modified form of glutathione (GSH) that undergoes rapid hydrolysis by esterases in vivo to restore GSH levels. It inhibits progression in the early stages of diabetes-associated cataract formation and reduces reactive oxygen species (ROS) content, thereby protecting in vitro mature bovine oocytes from oxidative stress.
In vitro
Methods: Glutathione ethyl ester (5 mM) was used to treat bovine oocytes, and the morphology of spindles and chromosomes was observed through immunofluorescence staining.
Results: Glutathione ethyl ester did not significantly improve the normal morphology of spindles, but it significantly reduced the proportion of oocytes with abnormal microtubule configurations after vitrification/warming. [1]
Chemical Properties
Molecular Weight335.38
FormulaC12H21N3O6S
Cas No.92614-59-0
SmilesCCOC(=O)CNC(=O)[C@H](CS)NC(=O)CC[C@H](N)C(O)=O
Relative Density.1.314 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (238.54 mM), Sonication is recommended.
H2O: 80 mg/mL (238.54 mM), Sonication is recommended.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM2.9817 mL14.9085 mL29.8169 mL149.0846 mL
5 mM0.5963 mL2.9817 mL5.9634 mL29.8169 mL
10 mM0.2982 mL1.4908 mL2.9817 mL14.9085 mL
20 mM0.1491 mL0.7454 mL1.4908 mL7.4542 mL
50 mM0.0596 mL0.2982 mL0.5963 mL2.9817 mL
100 mM0.0298 mL0.1491 mL0.2982 mL1.4908 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

ReactiveOxygenSpecies
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