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DMP 777

😃Good
Catalog No. T15144Cas No. 157341-41-8
Alias L-694458

DMP 777 is an orally active inhibitor of human leukocyte elastase.

DMP 777

DMP 777

😃Good
Catalog No. T15144Alias L-694458Cas No. 157341-41-8
DMP 777 is an orally active inhibitor of human leukocyte elastase.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$955 days5 days
5 mg$1635 days5 days
1 mL x 10 mM (in DMSO)$2275 days5 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
DMP 777 is an orally active inhibitor of human leukocyte elastase.
In vivo
DMP-777-treated animals show marked foveolar hyperplasia in the fundus with the prominent expansion of diastase-resistant, PAS-positive surface mucous cells. DMP-777-treated rats display a marked reduction in H/K-ATPase staining parietal cells. DMP-777-induced loss of parietal cells is significantly ameliorated with coadministration of omeprazole. When DMP-777 is coadministered with omeprazole, there is an obvious decrease in BrdU-positive S-phase cells compared with rats that received DMP-777 alone [1]. After DMP-777(40 mg/kg; p.o.; monkeys) treatment, the only stereoisomer detected in the post-dose plasma samples is the starting material DMP-777, and no inversion of the configuration at positions 'a' and 'b' of DMP-777 has occurred in vivo [2]. Mist1-/- mice treated with DMP-777 show fewer chief cells to SPEM transitions and which treated with L635 demonstrates significantly fewer proliferative SPEM cells compared to control mice [3].
SynonymsL-694458
Chemical Properties
Molecular Weight564.67
FormulaC31H40N4O6
Cas No.157341-41-8
Relative Density.1.227g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 38.33 mg/mL (67.88 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (3.54 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7709 mL8.8547 mL17.7095 mL88.5473 mL
5 mM0.3542 mL1.7709 mL3.5419 mL17.7095 mL
10 mM0.1771 mL0.8855 mL1.7709 mL8.8547 mL
20 mM0.0885 mL0.4427 mL0.8855 mL4.4274 mL
50 mM0.0354 mL0.1771 mL0.3542 mL1.7709 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

L694458L 694458Human leukocyte elastase (HLE)DMP-777DMP777DMP 777
Related Tags: buy DMP 777 | purchase DMP 777 | DMP 777 cost | order DMP 777 | DMP 777 chemical structure | DMP 777 in vivo | DMP 777 formula | DMP 777 molecular weight
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