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PF-562271 hydrochloride

Name: PF-562271 hydrochloride
Brand: TargetMol
SKU: T21768
Price: 71 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T21768Cas No. 939791-41-0

Alias PF-562271 HCl

PF-562271 hydrochloride (PF-562271 HCl) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.

PF-562271 hydrochloride

🥰Excellent

Purity: 97.08%

Catalog No. T21768Alias PF-562271 HClCas No. 939791-41-0

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$71	In Stock	In Stock
10 mg	$98	In Stock	In Stock
25 mg	$155	In Stock	In Stock
50 mg	$224	In Stock	In Stock
100 mg	$331	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.08%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	PF-562271 hydrochloride (PF-562271 HCl) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.
Targets&IC50	FAK:1.5 nM
Synonyms	PF-562271 HCl

Chemical Properties

Molecular Weight	543.95
Formula	C₂₁H₂₀F₃N₇O₃S HCl
Cas No.	939791-41-0
Smiles	Cl.CN(c1ncccc1CNc1nc(Nc2ccc3NC(=O)Cc3c2)ncc1C(F)(F)F)S(C)(=O)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 91 mg/mL (167.29 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8384 mL	9.1920 mL	18.3840 mL	91.9202 mL
5 mM	0.3677 mL	1.8384 mL	3.6768 mL	18.3840 mL
10 mM	0.1838 mL	0.9192 mL	1.8384 mL	9.1920 mL
20 mM	0.0919 mL	0.4596 mL	0.9192 mL	4.5960 mL
50 mM	0.0368 mL	0.1838 mL	0.3677 mL	1.8384 mL
100 mM	0.0184 mL	0.0919 mL	0.1838 mL	0.9192 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc