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VUF 5574
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Catalog No. T23518Cas No. 280570-45-8
VUF 5574 is a selective antagonist of adenosine A3 receptor with a Ki of 4.03 nM for the recombinant human receptor.
VUF 5574
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Purity: 99.53%
Catalog No. T23518Cas No. 280570-45-8
VUF 5574 is a selective antagonist of adenosine A3 receptor with a Ki of 4.03 nM for the recombinant human receptor.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $56 | - | In Stock | |
| 10 mg | $91 | - | In Stock | |
| 25 mg | $163 | - | In Stock | |
| 50 mg | $233 | - | In Stock | |
| 100 mg | $339 | - | In Stock | |
| 200 mg | $473 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.53%
Appearance:Solid
Color:White
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Product Introduction
VUF 5574 AI Summary
VUF 5574 exhibits a diverse range of bioactivities and binding affinities. It shows high affinity for the adenosine A3 receptor, with a Ki value of 4.0 nM, suggesting significant potential bioactivity related to this receptor subtype. Contrasting data indicates a differing affinity for the human adenosine A3 receptor with a Ki of 4030.0 nM. It can also displace [3H]DPCPX from the adenosine A1 receptor in rat brain cortical membrane by 52.0% at a 10 µM concentration and displaces [3H]CGS-21680 from the adenosine A2A receptor in rat striatal membrane by 43.0% at the same concentration. Additionally, VUF 5574 has demonstrated antiplasmodial activity against Plasmodium falciparum 7G8 with an IC50 value of 2511.89 nM after 72 hours by SYBR green assay. Exhibiting a broad spectrum of bioactivities, it has shown various inhibitory properties across multiple assays, affecting targets such as Lamin A Splicing, tau fibril formation, Cytochrome P450 enzymes, and others, with potencies ranging from 44.7 nM to 56234.1 nM. This indicates its effectiveness and potential therapeutic application in diverse biological processes..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | VUF 5574 is a selective antagonist of adenosine A3 receptor with a Ki of 4.03 nM for the recombinant human receptor. |
| Targets&IC50 | A3 receptor (human recombinant):4.03 nM (Ki) |
| Molecular Weight | 371.39 |
| Formula | C21H17N5O2 |
| Cas No. | 280570-45-8 |
| Smiles | COc1ccccc1NC(=O)Nc1nc(nc2ccccc12)-c1cccnc1 |
| Relative Density. | 1.36g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: Insoluble |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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