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Dihydrocortisol

Name: Dihydrocortisol
Brand: TargetMol
SKU: T9515
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9515 Copy Product Info

Purity: 99.83%

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Dihydrocortisol is a metabolite of hydrocortisone (cortisol) and a potential mineralocorticoid with inhibitory effects on Human cell line HEK293. It can elevate intraocular pressure by enhancing glucocorticoid activity and induce apoptosis in breast cancer cells.

Cas No. 1482-50-4

Pack Size	Price	USA Stock	Global Stock	Quantity
1 mg	$40	-	In Stock
5 mg	$91	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.83%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Dihydrocortisol is a metabolite of hydrocortisone (cortisol) and a potential mineralocorticoid with inhibitory effects on Human cell line HEK293. It can elevate intraocular pressure by enhancing glucocorticoid activity and induce apoptosis in breast cancer cells.
In vitro	Methods: MCF-7 cells were treated with different concentrations of 5β-Dihydrocortisol to detect cell viability and apoptosis level. The interaction between 5β-Dihydrocortisol and human serum albumin (HSA) was analyzed by fluorescence spectroscopy. Results: : 1.5β-Dihydrocortisol (10–100 μM, 48 h) could inhibit the viability of MCF-7 cells with an IC₅₀ of 27.59 μM. 2.5β-Dihydrocortisol (14 μM, 24 h) could induce early apoptosis (35.6%) and late apoptosis (2.5%) in MCF-7 cells. 3.5β-Dihydrocortisol (1–10 μM, 48 h) could quench the intrinsic fluorescence of human serum albumin (HSA), with the maximum emission peak at 360 nm and no obvious shift of the fluorescence peak position [2].
In vivo	Methods: The combined topical application of 5β-Dihydrocortisol and dexamethasone was performed on the eyes of young rabbits for 18 consecutive days, and changes in intraocular pressure (IOP) were detected. Results: 5β-Dihydrocortisol (0.1%–1.0%, administration for 18 days) could enhance the intraocular pressure-elevating effect of topical 0.06% dexamethasone in young rabbits [3].

Chemical Properties

Molecular Weight	364.48
Formula	C₂₁H₃₂O₅
Cas No.	1482-50-4
Smiles	C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](CC3)(CC(=O)CC4)[H])([C@@H](O)C1)[H])[H])(CC[C@@]2(C(CO)=O)O)[H]

Storage & Solubility Information

Storage

Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100.00 mg/mL (274.36 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7436 mL	13.7182 mL	27.4363 mL	137.1817 mL
5 mM	0.5487 mL	2.7436 mL	5.4873 mL	27.4363 mL
10 mM	0.2744 mL	1.3718 mL	2.7436 mL	13.7182 mL
20 mM	0.1372 mL	0.6859 mL	1.3718 mL	6.8591 mL
50 mM	0.0549 mL	0.2744 mL	0.5487 mL	2.7436 mL
100 mM	0.0274 mL	0.1372 mL	0.2744 mL	1.3718 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Keywords

11-β,17-α,21-TRIHYDROXY-5-β-PREGNANE-3,20-DIONE11BETA,17ALPHA,21TRIHYDROXY5BETAPREGNANE3,20DIONE11-b,17-a,21-TRIHYDROXY-5-b-PREGNANE-3,20-DIONE11 BETA,17 ALPHA,21 TRIHYDROXY 5 BETA PREGNANE 3,20 DIONE

Related Tags: Dihydrocortisol chemical structure | Dihydrocortisol in vivo | Dihydrocortisol in vitro | Dihydrocortisol formula | Dihydrocortisol molecular weight