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ABT-963 (Synonyms: ABT963, ABT 963)
Catalog No. T26531 Copy Product Info
Purity: 99.85%
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ABT-963 is a potent and selective inhibitor of disubstituted pyridazinone cyclooxygenase-2 (LOX2) that dose-dependently reduces injury perception in a carrageenan model of nociceptive sensitization.ABT-963 is used in the study of arthritis.
ABT-963
Copy Product Info😃Good
Catalog No. T26531
Synonyms ABT963, ABT 963
ABT-963 is a potent and selective inhibitor of disubstituted pyridazinone cyclooxygenase-2 (LOX2) that dose-dependently reduces injury perception in a carrageenan model of nociceptive sensitization.ABT-963 is used in the study of arthritis.
Cas No. 266320-83-6
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $176 | In Stock | In Stock | |
| 5 mg | $433 | In Stock | In Stock | |
| 10 mg | $592 | In Stock | In Stock | |
| 25 mg | $912 | In Stock | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
Batch Information
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Purity:99.85%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | ABT-963 is a potent and selective inhibitor of disubstituted pyridazinone cyclooxygenase-2 (LOX2) that dose-dependently reduces injury perception in a carrageenan model of nociceptive sensitization.ABT-963 is used in the study of arthritis. |
| In vivo | Following oral administration, ABT-963 decreased prostaglandin E2 production in a rat carrageenan airbag model (ED50 of 0.4 mg/kg) and reduced edema in a carrageenan-induced paw edema model with an ED30 of 1.9 mg/kg.ABT-963 dose-dependently decreased injury perception in a carrageenan nociceptive hypersensitivity model (ED50 of 3.1 mg/kg ). After 14 days of administration in an adjuvant arthritis model, ABT-963 had an ED(50) of 1.0 mg/kg in reducing hind paw swelling.[1] |
| Synonyms | ABT963, ABT 963 |
| Molecular Weight | 464.48 |
| Formula | C22H22F2N2O5S |
| Cas No. | 266320-83-6 |
| Smiles | O=C1C(OCCC(O)(C)C)=C(C=NN1C2=CC=C(F)C(F)=C2)C3=CC=C(C=C3)S(=O)(=O)C |
| Relative Density. | 1.34 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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