IL-22RA1 Protein, Human, Recombinant (His)

Name: IL-22RA1 Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPY-07014
Rating: 4.5 (1 reviews)

(Synonyms: IL22R1, IL22R, CRF2-9) Copy Product Info

Synonyms: IL22R1, IL22R, CRF2-9

Catalog No. TMPY-07014 Copy Product Info

IL-22RA1 Protein, Human, Recombinant (His) is expressed in HEK293 Cells. The accession number is Q8N6P7.

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Pack Size	Price	USA Stock	Global Stock
5 µg	$68	7-10 days	7-10 days
10 µg	$109	7-10 days	7-10 days
20 µg	$172	7-10 days	7-10 days
50 µg	$343	7-10 days	7-10 days
100 µg	$682	7-10 days	7-10 days
200 µg	$987	7-10 days	7-10 days
500 µg	$2,200	7-10 days	7-10 days
1 mg	$4,500	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Immobilized Human IL-22R alpha 1, His Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-IL-22R alpha 1 Antibody, hFc Tag with the EC50 of 6.4 ng/ml determined by ELISA (QC Test).
Description	IL-22RA1 Protein, Human, Recombinant (His) is expressed in HEK293 Cells. The accession number is Q8N6P7.
Species	Human
Expression System	HEK293 Cells
Tag	C-His
Accession Number	Q8N6P7
Construction	His16-Thr228
Protein Purity	> 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	IL22R1, IL22R, CRF2-9
Research Background	IL-22R belongs to the type II cytokine receptor family. It contains 2 fibronectin type-III domains and is expressed in the colon, liver, lung, pancreas, and kidney. IL-22R also can be expressed in keratinocytes of normal skin as well as in psoriatic skin lesions. Overexpression of IL-22R can be detected in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients. IL-22R is a component of the receptor for IL20, IL22, and IL24. The component of IL-22R formed by IL22RA1 and IL10RB enables IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptors for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. IL-22R mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.

Chemical Properties

Molecular Weight

25.67 kDa (predicted); 35-45 kDa (reducing contition, due to glycosylation)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.