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Butyrolactone 3

Name: Butyrolactone 3
Brand: TargetMol
SKU: T14839
Price: 67 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14839Cas No. 778649-18-6

Alias MB-3, MB3, MB 3

Butyrolactone 3 (MB-3) is a histone acetyltransferase Gcn5 inhibitor with a weak affinity for CBP.Butyrolactone 3 has antimicrobial activity and has been used in cancer, metabolic and neurological disorders.

Butyrolactone 3

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Purity: 99.5%

Catalog No. T14839Alias MB-3, MB3, MB 3Cas No. 778649-18-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$67	In Stock	In Stock
5 mg	$153	In Stock	In Stock
10 mg	$247	In Stock	In Stock
25 mg	$496	In Stock	In Stock
50 mg	$828	In Stock	In Stock
100 mg	$1,090	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.5%

Appearance:Solid

Color:White to Pink

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Butyrolactone 3 (MB-3) is a histone acetyltransferase Gcn5 inhibitor with a weak affinity for CBP.Butyrolactone 3 has antimicrobial activity and has been used in cancer, metabolic and neurological disorders.
Targets&IC50	GCN5:100 μM
In vitro	Butyrolactone 3 (50, 100, 200 μM; 16 h; RCH-ACV cells) can reduce Gcn5 acetylation and induces E2A-PBX1 degradation. Butyrolactone 3 decreased the protein levels of E2A-PBX1 and E2A in a dose-dependent manner, and reduced Wnt16 and GCN5 protein levels.[3]
Synonyms	MB-3, MB3, MB 3

Chemical Properties

Molecular Weight	184.19
Formula	C₉H₁₂O₄
Cas No.	778649-18-6
Smiles	CCC[C@H]1OC(=O)C(=C)[C@@H]1C(O)=O
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (814.38 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (17.92 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.4292 mL	27.1459 mL	54.2918 mL	271.4588 mL
5 mM	1.0858 mL	5.4292 mL	10.8584 mL	54.2918 mL
10 mM	0.5429 mL	2.7146 mL	5.4292 mL	27.1459 mL
20 mM	0.2715 mL	1.3573 mL	2.7146 mL	13.5729 mL
50 mM	0.1086 mL	0.5429 mL	1.0858 mL	5.4292 mL
100 mM	0.0543 mL	0.2715 mL	0.5429 mL	2.7146 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc