C-ABL/ABL1 Protein, Mouse, Recombinant (His)

Name: C-ABL/ABL1 Protein, Mouse, Recombinant (His)
Brand: TargetMol
SKU: TMPC-00003
Rating: 4.5 (1 reviews)

(Synonyms: Tyrosine-protein kinase ABL1, Proto-oncogene c-Abl, p150, Abl1, Abl, Abelson tyrosine-protein kinase 1) Copy Product Info

Synonyms: Tyrosine-protein kinase ABL1, Proto-oncogene c-Abl, p150, Abl1, Abl, Abelson tyrosine-protein kinase 1

Catalog No. TMPC-00003 Copy Product Info

C-ABL/ABL1 Protein, Mouse, Recombinant (His) is expressed in Baculovirus-Insect Cells. The accession number is P00520.

Pack Size	Price	USA Stock	Global Stock	Quantity
10 µg	$1,390	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	The specific activity of ABL1 was determined to be >300 nmol/min/mg by ADP-Glo kinase assay.
Description	C-ABL/ABL1 Protein, Mouse, Recombinant (His) is expressed in Baculovirus-Insect Cells. The accession number is P00520.
Species	Mouse
Expression System	Baculovirus-Insect Cells
Tag	N-His
Accession Number	P00520
Construction	Recombinant mouse ABL1 (27-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Protein Purity	>70% as determined by SDS-PAGE.
Formulation	Supplied as sterile 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol.
Synonyms	Tyrosine-protein kinase ABL1, Proto-oncogene c-Abl, p150, Abl1, Abl, Abelson tyrosine-protein kinase 1
Research Background	c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity and tau phosphorylation. c-Abl has been implicated in many cellular processes including differentiation, division, adhesion, death, and stress response. c-Abl is a latent tyrosine kinase that becomes activated in response to numerous extra- and intra-cellular stimuli. The c-Abl protein is a ubiquitously expressed nonreceptor tyrosine kinase involved in the development and function of many mammalian organ systems, including the immune system and bone. It regulates the cellular response to TAM through functional interaction with the estrogen receptor, which suggests c-Abl as a therapeutic target and a prognostic tumor marker for breast cancer. c-Abl also plays a key role in signaling chemokine-induced T-cell migration. In addition, c-Abl contains NLSs (nuclear localization signals) and DNA-binding sequences important for nuclear functions. c-Abl has become an important therapeutic target in human chronic myeloid leukaemia.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

Chemical Properties

Molecular Weight

~135 kDa

Storage & Solubility Information

Shipping	Enzymes are highly recommended to be shipped at frozen temperature with dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.