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ERDRP-0519

Name: ERDRP-0519
Brand: TargetMol
SKU: T24040
Price: 139 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24040Cas No. 1374006-96-8

Alias ERDRP0519, ERDRP 0519

ERDRP-0519 is an orally bioavailable small-molecule inhibitor of the Measles virus (MeV) polymerase. It effectively prevents measles disease in squirrel monkeys (Saimiri sciureus) and exhibits potent inhibition of morbilliviruses in the nanomolar range.

ERDRP-0519

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Purity: 98.71%

Catalog No. T24040Alias ERDRP0519, ERDRP 0519Cas No. 1374006-96-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$139	In Stock	In Stock
5 mg	$347	In Stock	In Stock
10 mg	$488	In Stock	In Stock
25 mg	$785	In Stock	In Stock
50 mg	$1,120	-	In Stock
100 mg	$1,480	-	In Stock
1 mL x 10 mM (in DMSO)	$382	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.71%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	ERDRP-0519 is an orally bioavailable small-molecule inhibitor of the Measles virus (MeV) polymerase. It effectively prevents measles disease in squirrel monkeys (Saimiri sciureus) and exhibits potent inhibition of morbilliviruses in the nanomolar range.
In vitro	ERDRP-0519 demonstrates potency against various Measles virus (MeV) isolates, with EC50 values ranging from 0.07 to 0.3 µM[1], and is also effective against MeV and related Morbillivirus pathogens, such as canine distemper virus (CDV)[3].
In vivo	A single-dose pharmacokinetic study was conducted in squirrel monkeys through oral administration of ERDRP-0519 at a dose of 50 mg/kg, with blood samples collected at seven predetermined time points following the dose. The peak serum concentrations of ERDRP-0519 were observed approximately 2 hours post-administration, reaching a maximum (Cmax) of 3.27 µM.
Synonyms	ERDRP0519, ERDRP 0519

Chemical Properties

Molecular Weight	529.58
Formula	C₂₃H₃₀F₃N₅O₄S
Cas No.	1374006-96-8
Smiles	Cn1nc(cc1C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCCC[C@H]1CCN1CCOCC1)C(F)(F)F
Relative Density.	1.44 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (169.95 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.23 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8883 mL	9.4414 mL	18.8829 mL	94.4144 mL
5 mM	0.3777 mL	1.8883 mL	3.7766 mL	18.8829 mL
10 mM	0.1888 mL	0.9441 mL	1.8883 mL	9.4414 mL
20 mM	0.0944 mL	0.4721 mL	0.9441 mL	4.7207 mL
50 mM	0.0378 mL	0.1888 mL	0.3777 mL	1.8883 mL
100 mM	0.0189 mL	0.0944 mL	0.1888 mL	0.9441 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc