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ERDRP-0519

Name: ERDRP-0519
Brand: TargetMol
SKU: T24040
Price: 139 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T24040Cas No. 1374006-96-8

Alias ERDRP0519, ERDRP 0519

ERDRP-0519 is an orally bioavailable small-molecule inhibitor of the Measles virus (MeV) polymerase. It effectively prevents measles disease in squirrel monkeys (Saimiri sciureus) and exhibits potent inhibition of morbilliviruses in the nanomolar range.

ERDRP-0519

🥰Excellent

Purity: 98.71%

Catalog No. T24040Alias ERDRP0519, ERDRP 0519Cas No. 1374006-96-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$139	In Stock	In Stock
5 mg	$347	In Stock	In Stock
10 mg	$488	In Stock	In Stock
25 mg	$785	In Stock	In Stock
50 mg	$1,120	-	In Stock
100 mg	$1,480	-	In Stock
1 mL x 10 mM (in DMSO)	$382	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.71%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	ERDRP-0519 is an orally bioavailable small-molecule inhibitor of the Measles virus (MeV) polymerase. It effectively prevents measles disease in squirrel monkeys (Saimiri sciureus) and exhibits potent inhibition of morbilliviruses in the nanomolar range.
In vitro	ERDRP-0519 demonstrates potency against various Measles virus (MeV) isolates, with EC50 values ranging from 0.07 to 0.3 µM[1], and is also effective against MeV and related Morbillivirus pathogens, such as canine distemper virus (CDV)[3].
In vivo	A single-dose pharmacokinetic study was conducted in squirrel monkeys through oral administration of ERDRP-0519 at a dose of 50 mg/kg, with blood samples collected at seven predetermined time points following the dose. The peak serum concentrations of ERDRP-0519 were observed approximately 2 hours post-administration, reaching a maximum (Cmax) of 3.27 µM.
Synonyms	ERDRP0519, ERDRP 0519

Chemical Properties

Molecular Weight	529.58
Formula	C₂₃H₃₀F₃N₅O₄S
Cas No.	1374006-96-8
Smiles	Cn1nc(cc1C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCCC[C@H]1CCN1CCOCC1)C(F)(F)F
Relative Density.	1.44 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (169.95 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.23 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8883 mL	9.4414 mL	18.8829 mL	94.4144 mL
5 mM	0.3777 mL	1.8883 mL	3.7766 mL	18.8829 mL
10 mM	0.1888 mL	0.9441 mL	1.8883 mL	9.4414 mL
20 mM	0.0944 mL	0.4721 mL	0.9441 mL	4.7207 mL
50 mM	0.0378 mL	0.1888 mL	0.3777 mL	1.8883 mL
100 mM	0.0189 mL	0.0944 mL	0.1888 mL	0.9441 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc