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Synonyms: P-130, P130, P 130, MGC-142024, MGC142024, MGC-138218, MGC138218, MGC 142024, MGC 138218, liver-intestine, LI-cadherin, HPT-1, HPT1, HPT 1, FLJ-26931, FLJ26931, FLJ 26931, Cdh17, CDH-16, CDH16, CDH 16, Cadherin-17, cadherin-16, cadherin 17, LI cadherin (liver-intestine), cadherin 17, LI cadherin, BILL-cadherin


| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $74 | 7-10 days | 7-10 days | |
| 10 µg | $113 | 7-10 days | 7-10 days | |
| 20 µg | $175 | 7-10 days | 7-10 days | |
| 50 µg | $316 | 7-10 days | 7-10 days | |
| 100 µg | $490 | 7-10 days | 7-10 days | |
| 200 µg | $793 | 7-10 days | 7-10 days | |
| 500 µg | $1,470 | 7-10 days | 7-10 days |
| Bioactivity | Immobilized Human CDH17, Llama IgG2b Fc Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Anti-CDH17 Antibody, hFc Avi Tag with the EC50 of 11.2 ng/ml determined by ELISA (QC Test). |
| Description | Cadherin 17/CDH17 Protein, Human, Recombinant (LlaFc) is expressed in HEK293 Cells. The accession number is Q12864-1. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-Llama IgG2b Fc |
| Accession Number | Q12864-1 |
| Construction | Gln23-Met787 |
| Protein Purity | > 90% as determined by Bis-Tris PAGE |
| Endotoxin | < 0.1 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from 0.22 μm filtered solution in 20 mM Tris, 150 mM NaCl (pH 8.0). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Synonyms | P-130, P130, P 130, MGC-142024, MGC142024, MGC-138218, MGC138218, MGC 142024, MGC 138218, liver-intestine, LI-cadherin, HPT-1, HPT1, HPT 1, FLJ-26931, FLJ26931, FLJ 26931, Cdh17, CDH-16, CDH16, CDH 16, Cadherin-17, cadherin-16, cadherin 17, LI cadherin (liver-intestine), cadherin 17, LI cadherin, BILL-cadherin |
| Research Background | Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades. In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. |
| Molecular Weight | 112.28 kDa (Predicted); 120-140 kDa (Reducing condition, due to glycosylation) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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