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JAK-IN-14

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Catalog No. T9764Cas No. 1973485-06-1

JAK-IN-14 (compound 16) is a specific JAK1 inhibitor with IC50<5 μM. It prevents JAK1 phosphorylation by binding to the active site of JAK1, and is more than 8-fold selective for JAK1 over JAK2/JAK3, and can be used in immune, inflammation and cancer research.

JAK-IN-14

JAK-IN-14

🥰Excellent
Purity: 98.27%
Catalog No. T9764Cas No. 1973485-06-1
JAK-IN-14 (compound 16) is a specific JAK1 inhibitor with IC50<5 μM. It prevents JAK1 phosphorylation by binding to the active site of JAK1, and is more than 8-fold selective for JAK1 over JAK2/JAK3, and can be used in immune, inflammation and cancer research.
Pack SizePriceAvailabilityQuantity
1 mg$81In Stock
5 mg$198In Stock
10 mg$312In Stock
25 mg$648In Stock
50 mg$987In Stock
100 mg$1,570In Stock
200 mg$2,090In Stock
1 mL x 10 mM (in DMSO)$219In Stock
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Purity:98.27%
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Product Introduction

Bioactivity
Description
JAK-IN-14 (compound 16) is a specific JAK1 inhibitor with IC50<5 μM. It prevents JAK1 phosphorylation by binding to the active site of JAK1, and is more than 8-fold selective for JAK1 over JAK2/JAK3, and can be used in immune, inflammation and cancer research.
Chemical Properties
Molecular Weight334.35
FormulaC19H15FN4O
Cas No.1973485-06-1
SmilesN#CCC=1C=CC(=C(F)C1)C2=CC=CC3=NC(=CN32)NC(=O)C4CC4
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 5 mg/mL (14.95 mM), Sonication and heating are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9909 mL14.9544 mL29.9088 mL149.5439 mL
5 mM0.5982 mL2.9909 mL5.9818 mL29.9088 mL
10 mM0.2991 mL1.4954 mL2.9909 mL14.9544 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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