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Alloxan monohydrate

Name: Alloxan monohydrate
Brand: TargetMol
SKU: T7814
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7814Cas No. 2244-11-3

Alloxan Monohydrate is a diabetogenic agent that acts as a proteasome inhibitor and induces diabetes in experimental animals by damaging the insulin-secreting β-cells in the pancreas. It is commonly used to establish diabetes models.

Alloxan monohydrate

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Purity: 99.42%

Catalog No. T7814Cas No. 2244-11-3

Pack Size	Price	Availability	Quantity
1 g	$29	In Stock

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Batch Information

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Purity:99.42%

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COA HPLC

Product Introduction

Bioactivity

Description	Alloxan Monohydrate is a diabetogenic agent that acts as a proteasome inhibitor and induces diabetes in experimental animals by damaging the insulin-secreting β-cells in the pancreas. It is commonly used to establish diabetes models.
In vitro	Alloxan caused the accumulation of ubiquitinated proteins in NRK cells through the inhibition of the proteolytic activities of the proteasome.?Alloxan directly acts on the chymotrypsin- and trypsin-like peptidase activities[1]

Chemical Properties

Molecular Weight	160.09
Formula	C₄H₄N₂O₅
Cas No.	2244-11-3
Smiles	O.O=C1NC(=O)C(=O)C(=O)N1
Relative Density.	1.681g/cm3

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (374.79 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.49 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.2465 mL	31.2324 mL	62.4649 mL	312.3243 mL
5 mM	1.2493 mL	6.2465 mL	12.4930 mL	62.4649 mL
10 mM	0.6246 mL	3.1232 mL	6.2465 mL	31.2324 mL
20 mM	0.3123 mL	1.5616 mL	3.1232 mL	15.6162 mL
50 mM	0.1249 mL	0.6246 mL	1.2493 mL	6.2465 mL
100 mM	0.0625 mL	0.3123 mL	0.6246 mL	3.1232 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc