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JNJ-46778212

Name: JNJ-46778212
Brand: TargetMol
SKU: T15619
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15619Cas No. 1363281-27-9

Alias VU 0409551

JNJ-46778212 (VU 0409551) is a potent and selective mGlu5 allosteric modulator (EC50: 260 nM) used for neurodissection studies.

JNJ-46778212

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Purity: 99.24%

Catalog No. T15619Alias VU 0409551Cas No. 1363281-27-9

JNJ-46778212 (VU 0409551) is a potent and selective mGlu5 allosteric modulator (EC50: 260 nM) used for neurodissection studies.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$34	-	In Stock
10 mg	$59	-	In Stock
25 mg	$128	-	In Stock
50 mg	$218	-	In Stock
100 mg	$349	-	In Stock
1 mL x 10 mM (in DMSO)	$37	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.24%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	JNJ-46778212 (VU 0409551) is a potent and selective mGlu5 allosteric modulator (EC50: 260 nM) used for neurodissection studies.
Targets&IC50	mGlu5:260 nM (EC50)
In vivo	JNJ-46778212 exhibits dose-dependent antipsychotic-like activity in rats (3-56.6 mg/kg, po) and reverses AHL[1].
Synonyms	VU 0409551

Chemical Properties

Molecular Weight	352.36
Formula	C₂₀H₁₇FN₂O₃
Cas No.	1363281-27-9
Smiles	Fc1ccc(cc1)C(=O)N1CCc2nc(COc3ccccc3)oc2C1
Relative Density.	1.308 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (227.04 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (9.37 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8380 mL	14.1900 mL	28.3801 mL	141.9003 mL
5 mM	0.5676 mL	2.8380 mL	5.6760 mL	28.3801 mL
10 mM	0.2838 mL	1.4190 mL	2.8380 mL	14.1900 mL
20 mM	0.1419 mL	0.7095 mL	1.4190 mL	7.0950 mL
50 mM	0.0568 mL	0.2838 mL	0.5676 mL	2.8380 mL
100 mM	0.0284 mL	0.1419 mL	0.2838 mL	1.4190 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc