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(-)-Hydroxycitric acid lactone

🥰Excellent
Catalog No. T12045Cas No. 27750-13-6
Alias Garcinia lactone

(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a potent inhibitor of ATP citrate lyase, an enzyme that catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA.

(-)-Hydroxycitric acid lactone

(-)-Hydroxycitric acid lactone

🥰Excellent
Purity: 99.91%
Catalog No. T12045Alias Garcinia lactoneCas No. 27750-13-6
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a potent inhibitor of ATP citrate lyase, an enzyme that catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA.
Pack SizePriceAvailabilityQuantity
1 mg$64In Stock
2 mg$93In Stock
5 mg$155In Stock
10 mg$247In Stock
25 mg$418In Stock
50 mg$596In Stock
1 mL x 10 mM (in DMSO)$123In Stock
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Purity:99.91%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a potent inhibitor of ATP citrate lyase, an enzyme that catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA.
In vivo
Garcinia lactone fed chicken for a period of 4 weeks significantly decreases body weight at 2000 and 3000 mg/kg[2].
SynonymsGarcinia lactone
Chemical Properties
Molecular Weight190.11
FormulaC6H6O7
Cas No.27750-13-6
SmilesOC(=O)[C@H]1OC(=O)C[C@@]1(O)C(O)=O
Relative Density.1.976 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 60 mg/mL (315.61 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.52 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM5.2601 mL26.3006 mL52.6011 mL263.0056 mL
5 mM1.0520 mL5.2601 mL10.5202 mL52.6011 mL
10 mM0.5260 mL2.6301 mL5.2601 mL26.3006 mL
20 mM0.2630 mL1.3150 mL2.6301 mL13.1503 mL
50 mM0.1052 mL0.5260 mL1.0520 mL5.2601 mL
100 mM0.0526 mL0.2630 mL0.5260 mL2.6301 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

weight-controllingsynthesisintakeInhibitorinhibitHydroxycitric acid lactoneHIFfoodfatderivativeATPCitrateLyaseATP Citrate LyaseATP citrate lyaseagentACLY()Hydroxycitric acid lactone( ) Hydroxycitric acid lactone
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