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KCNQ1 activator-1

Name: KCNQ1 activator-1
Brand: TargetMol
SKU: T9778
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9778Cas No. 1008671-38-2

2-Piperidinecarboxamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-(phenylsulfonyl)- is a potent KCNQ1 channel activator that can be used in long QT syndrome (LQTS) studies.

KCNQ1 activator-1

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Purity: 99.71%

Catalog No. T9778Cas No. 1008671-38-2

2-Piperidinecarboxamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-(phenylsulfonyl)- is a potent KCNQ1 channel activator that can be used in long QT syndrome (LQTS) studies.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$36	-	In Stock
5 mg	$86	-	In Stock
10 mg	$139	-	In Stock
25 mg	$243	-	In Stock
50 mg	$361	-	In Stock
100 mg	$513	-	In Stock
200 mg	$727	-	In Stock
1 mL x 10 mM (in DMSO)	$103	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.71%

Appearance:Solid

Color:Yellow

Resource Download

COA HPLC HNMR

Product Introduction

KCNQ1 activator-1 AI Summary

KCNQ1 activator-1 demonstrates a wide range of bioactivities across various assays. It is known to modulate splicing and enhance SMN2 splice variant expression. Additionally, it inhibits tau fibril formation, influences lipid storage modulators, targets the Menin-MLL interaction in leukemias, and inhibits the malaria parasite's plastid function. The compound also interacts with Marburg and Lassa viruses, induces DNA re-replication, and inhibits both the Hepatitis C Virus and GLP-1 receptor. It acts on Pin1 and provides integrin-mediated alleviation for muscular dystrophy. Moreover, it serves as an inhibitor of TDP-1, TDP-43, and PTHR, and functions as a stage-specific inhibitor of Vaccinia Orthopoxvirus. Notably, KCNQ1 activator-1 activates the Kv7.1 channel expressed in CHO cells, leading to depolarization-induced thallium influx within 3 minutes, as determined by patch clamp assay. It has an EC50 of 1690.0 nM and shows a relative activation of 285.0% compared to the control in the same assay, highlighting its effectiveness in modulating the Kv7.1 channel..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

2-Piperidinecarboxamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-(phenylsulfonyl)- is a potent KCNQ1 channel activator that can be used in long QT syndrome (LQTS) studies.

Chemical Properties

Molecular Weight	457.57
Formula	C₂₂H₂₃N₃O₄S₂
Cas No.	1008671-38-2
Smiles	COc1ccc(cc1)-c1csc(NC(=O)C2CCCCN2S(=O)(=O)c2ccccc2)n1

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (546.36 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (7.21 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1855 mL	10.9273 mL	21.8546 mL	109.2729 mL
5 mM	0.4371 mL	2.1855 mL	4.3709 mL	21.8546 mL
10 mM	0.2185 mL	1.0927 mL	2.1855 mL	10.9273 mL
20 mM	0.1093 mL	0.5464 mL	1.0927 mL	5.4636 mL
50 mM	0.0437 mL	0.2185 mL	0.4371 mL	2.1855 mL
100 mM	0.0219 mL	0.1093 mL	0.2185 mL	1.0927 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc