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NUN82647
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Catalog No. T8331Cas No. 16082-64-7
Alias CU-242
NUN82647 (CU-242) is an Inhibitor of cell cycle at G2 phase, and apoptosis inducer.
NUN82647
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Purity: 98.91%
Catalog No. T8331Alias CU-242Cas No. 16082-64-7
NUN82647 (CU-242) is an Inhibitor of cell cycle at G2 phase, and apoptosis inducer.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $39 | In Stock | In Stock | |
| 5 mg | $89 | In Stock | In Stock | |
| 10 mg | $143 | In Stock | In Stock | |
| 25 mg | $263 | In Stock | In Stock | |
| 50 mg | $396 | In Stock | In Stock | |
| 100 mg | $579 | In Stock | In Stock | |
| 200 mg | $783 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $88 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.91%
Appearance:Solid
Color:White
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Product Introduction
NUN82647 AI Summary
NUN82647 exhibits a range of bioactivities. It stabilizes human IkappaBalpha in OCI-Ly3 cells with an EC50 of 11000.0 nM and achieves 300.0% efficacy relative to control. It effectively inhibits TNF-alpha-stimulated human NF-kappaB p65 RelA subunit nuclear translocation in HUVEC with an efficacy greater than 90.0% and an IC50 of 2000.0 nM. Additionally, it inhibits TNFalpha-stimulated human NF-kappaB-mediated beta-lactamase gene expression in HUVEC with an IC50 of 13500.0 nM and shows cytotoxicity against NF-kappaB overexpressing OCI-Ly3 cells with an IC50 exceeding 57000.0 nM. Beyond NF-kappaB inhibition, NUN82647 inhibits a variety of enzymatic and protein-protein interactions, including those involving TDP1, ROR gamma, menin-MLL in leukemias, and several others related to infectious diseases like Giardia Lamblia and viruses like Lassa and Marburg. Importantly, it has an IC50 value greater than 10420.0 nM when tested against Human African Trypanosomiasis (HAT) and shows antagonist activity by inhibiting hepcidin-induced ferroportin internalization in MDCK cells with an IC50 of 20800.0 nM..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | NUN82647 (CU-242) is an Inhibitor of cell cycle at G2 phase, and apoptosis inducer. |
| Synonyms | CU-242 |
| Molecular Weight | 299.35 |
| Formula | C15H13N3O2S |
| Cas No. | 16082-64-7 |
| Smiles | Nc1ccccc1S(=O)(=O)Nc1cccc2cccnc12 |
| Relative Density. | 1.437 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 25 mg/mL (83.51 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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