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SID-852843

Name: SID-852843
Brand: TargetMol
SKU: T73097
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T73097Cas No. 909859-19-4

SID-852843 is a WNV NS2B-NS3 protease inhibitor with an IC50 value of 0.105 μM for WNV NS2B-NS3 protease and can be used for the study of viral infections.

SID-852843

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Purity: 99.59%

Catalog No. T73097Cas No. 909859-19-4

SID-852843 is a WNV NS2B-NS3 protease inhibitor with an IC50 value of 0.105 μM for WNV NS2B-NS3 protease and can be used for the study of viral infections.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	In Stock	In Stock
5 mg	$58	In Stock	In Stock
10 mg	$93	In Stock	In Stock
25 mg	$188	In Stock	In Stock
50 mg	$292	In Stock	In Stock
100 mg	$419	-	In Stock
200 mg	$587	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.59%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

SID-852843 AI Summary

SID-852843 inhibits the West Nile Virus NS2B-NS3 protease with a potent IC50 value of 105.0 nM, as shown in a fluorescence assay. Additionally, this compound demonstrates inhibitory activity against a variety of other biological targets with varying potencies. It inhibits Lamin A splicing (IC50 = 3548.1 nM), Ubiquitin-specific Protease USP2a (IC50 = 1258.9 nM), and Aldehyde Dehydrogenase 1 (ALDH1A1) with an IC50 of 1778.3 nM. Moreover, it exhibits lower potency against targets like the MLL CXXC domain - DNA interaction (IC50 = 28183.8 nM) and Tau fibril formation (IC50 = 10000.0 nM). SID-852843 also inhibits the N-terminal His6-tagged Zika Virus NS2B-NS3 protease domain with an IC50 of 1500.0 nM, showing its broad-spectrum antiviral potential. Its multifaceted bioactivity profile includes roles as an inhibitor of Influenza NS1 protein function (IC50 = 11220.2 nM), HPGD (IC50 = 17782.8 nM), HADH2 (IC50 = 15848.9 nM), and re-activator of p53 (IC50 = 50118.7 nM), among others. Despite its broad range of targets, it is notably potent as an antiviral against the West Nile Virus..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	SID-852843 is a WNV NS2B-NS3 protease inhibitor with an IC50 value of 0.105 μM for WNV NS2B-NS3 protease and can be used for the study of viral infections.
Targets&IC50	WNV NS2B-NS3:0.105 μM

Chemical Properties

Molecular Weight	373.38
Formula	C₁₇H₁₅N₃O₅S
Cas No.	909859-19-4
Smiles	S(=O)(=O)(N1N=C(OC(=O)C2=CC=CC=C2)C=C1N)C3=CC=C(OC)C=C3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (241.04 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.84 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6782 mL	13.3912 mL	26.7824 mL	133.9118 mL
5 mM	0.5356 mL	2.6782 mL	5.3565 mL	26.7824 mL
10 mM	0.2678 mL	1.3391 mL	2.6782 mL	13.3912 mL
20 mM	0.1339 mL	0.6696 mL	1.3391 mL	6.6956 mL
50 mM	0.0536 mL	0.2678 mL	0.5356 mL	2.6782 mL
100 mM	0.0268 mL	0.1339 mL	0.2678 mL	1.3391 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc