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Raloxifene

Name: Raloxifene
Brand: TargetMol
SKU: T20419
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20419Cas No. 84449-90-1

Alias Raloxifenum, Pharoxifene, LY156758 free base, LY139481, LY1 39481, Keoxifene

Raloxifene (LY139481) is a selective estrogen receptor modulator that exhibits both estrogen agonist and antagonist activities at certain sites, with antiviral activity against viruses like Ebola, influenza, and HCV, useful for studying viral infections.

Raloxifene

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Purity: 99.39%

Catalog No. T20419Alias Raloxifenum, Pharoxifene, LY156758 free base, LY139481, LY1 39481, KeoxifeneCas No. 84449-90-1

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	In Stock	In Stock
5 mg	$56	In Stock	In Stock
10 mg	$98	In Stock	In Stock
25 mg	$197	In Stock	In Stock
50 mg	$293	In Stock	In Stock
100 mg	$435	In Stock	In Stock
200 mg	$629	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$59	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.39%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Raloxifene (LY139481) is a selective estrogen receptor modulator that exhibits both estrogen agonist and antagonist activities at certain sites, with antiviral activity against viruses like Ebola, influenza, and HCV, useful for studying viral infections.
In vitro	Raloxifene (10 μM and 50 μM) treated cells showed an increase in the percentage of cells with fragmented nuclei of 31 to 41 percent and 45 to 66 percent, respectively, after 12 and 24 hours of exposure. Treatment with Raloxifene (50 μM) resulted in increased autophagy activity in host cells, helping to prevent intracellular bacterial invasion and proliferation. [1] Treatment with Raloxifene((40-100 μM) prevented the dissolution of stress particles (SG) and promoted cell death during hypoxia of U251 and U3024 primary glioblastoma (GBM) cells. [4]
In vivo	Raloxifene (10 mg/kg) induced significant reductions of urea and creatinine, TNF-α, IL-1β and caspase-3 in renal isis-reperfusion injury mouse models, suggesting renal protection. [2] Treatment with Raloxifene (10 mg/kg) alleviates vision defects caused by initial cell injury (OBI) and may be associated with a reduction in the proinflammatory effects of microglia. [3]
Synonyms	Raloxifenum, Pharoxifene, LY156758 free base, LY139481, LY1 39481, Keoxifene

Chemical Properties

Molecular Weight	473.58
Formula	C₂₈H₂₇NO₄S
Cas No.	84449-90-1
Smiles	O=C(C1=CC=C(OCCN2CCCCC2)C=C1)C3=C(SC4=CC(O)=CC=C43)C=5C=CC(O)=CC5
Relative Density.	1.289 g/cm3

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 29.41 mg/mL (62.1 mM), Sonication is recommended.

Ethanol: 9 mg/mL (19 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1116 mL	10.5579 mL	21.1158 mL	105.5788 mL
5 mM	0.4223 mL	2.1116 mL	4.2232 mL	21.1158 mL
10 mM	0.2112 mL	1.0558 mL	2.1116 mL	10.5579 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1056 mL	0.5279 mL	1.0558 mL	5.2789 mL
50 mM	0.0422 mL	0.2112 mL	0.4223 mL	2.1116 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc