Shopping Cart

Your shopping cart is currently empty

Theaflavin 3,3′-digallate

Name: Theaflavin 3,3′-digallate
Brand: TargetMol
SKU: T5429
Price: 84 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T5429Cas No. 30462-35-2

Alias Theaflavin 3,3′-di-O-gallate, Theaflavin 3, TFDG

Theaflavin 3,3'-digallate, a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregulating HIF-1αand VEGF.

Theaflavin 3,3′-digallate

😃Good

Purity: 99.86%

Catalog No. T5429Alias Theaflavin 3,3′-di-O-gallate, Theaflavin 3, TFDGCas No. 30462-35-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$84	In Stock	In Stock
5 mg	$182	In Stock	In Stock
10 mg	$297	In Stock	In Stock
25 mg	$513	In Stock	In Stock
50 mg	$718	In Stock	In Stock
100 mg	$969	-	In Stock
200 mg	$1,280	-	In Stock
1 mL x 10 mM (in DMSO)	$297	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.86%

Color:White

Resource Download

COA

Product Introduction

Bioactivity

Description	Theaflavin 3,3'-digallate, a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregulating HIF-1αand VEGF.
In vitro	Theaflavin 3,3'-digallate (TF-3) significantly reduces viral RNA levels and the expression of NS3 and U87 MG proteins in a dose-dependent manner when used at concentrations of 6.25, 12.5, and 25 μM for 24 hours [1]. Theaflavin 3,3'-digallate demonstrates potent antiviral activity against ZIKV replication in Vero E6 cells (EC50: 7.65 μM), while showing minimal cytotoxicity at doses up to 40 μM. Theaflavin 3,3'-digallate interferes with the post-entry phases of the ZIKV replication cycle, disrupting gene transcription and translation [1]. Theaflavin 3,3'-digallate leads to a rapid and sustained reduction in phospho-ERK1/2 and phospho-MEK1/2 protein levels and inhibits HCT116 cell growth (IC50: 17.26 μM) [2].
In vivo	In vivo, Theaflavin 3,3'-digallatereduces serum levels of TNF-α, IL-1β, and IL-6 and decreases pulmonary edema, pulmonary congestion, and thickening of the alveolar wall in a mouse model of LPS-induced acute lung injury. It also inhibits osteoclast formation, polarization, and osteoclastic bone resorption in vitro and reduces titanium particle-induced bone erosion and the number of mature osteoclasts in mice in a dose-dependent manner [3].
Synonyms	Theaflavin 3,3′-di-O-gallate, Theaflavin 3, TFDG

Chemical Properties

Molecular Weight	868.70
Formula	C₄₃H₃₂O₂₀
Cas No.	30462-35-2
Smiles	Oc1cc(O)c2C[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](Oc2c1)c1cc(O)c(O)c2c1cc(cc(O)c2=O)[C@H]1Oc2cc(O)cc(O)c2C[C@H]1OC(=O)c1cc(O)c(O)c(O)c1
Relative Density.	1.978 g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 117.50 mg/mL (135.26 mM), Sonication is recommended.

Ethanol: 10.00 mg/mL (11.51 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1.00 mg/mL (1.15 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1511 mL	5.7557 mL	11.5115 mL	57.5573 mL
5 mM	0.2302 mL	1.1511 mL	2.3023 mL	11.5115 mL
10 mM	0.1151 mL	0.5756 mL	1.1511 mL	5.7557 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.0576 mL	0.2878 mL	0.5756 mL	2.8779 mL
50 mM	0.0230 mL	0.1151 mL	0.2302 mL	1.1511 mL
100 mM	0.0115 mL	0.0576 mL	0.1151 mL	0.5756 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc