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BML-259

Catalog No. T36964 CAS 267654-00-2

Synonyms: CAY10554

BML-259 is an inhibitor of CDK5 and CDK2 with IC50s of 64 and 98 nM, respectively. BML-259 can be used in studies about the treatment of cancer and neurodegenerative diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

BML-259, CAS 267654-00-2

Pack Size	Availability	Price/USD
5 mg	In stock	$ 43.00
10 mg	In stock	$ 77.00
25 mg	In stock	$ 172.00
50 mg	In stock	$ 293.00
100 mg	In stock	$ 513.00
500 mg	In stock	$ 1,090.00
1 mL * 10 mM (in DMSO)	In stock	$ 48.00

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Purity: 99.68%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BML-259 is an inhibitor of CDK5 and CDK2 with IC50s of 64 and 98 nM, respectively. BML-259 can be used in studies about the treatment of cancer and neurodegenerative diseases.
In vitro	BML-259 prevents a large population of cells from NAC-evoked cell death[1].

Synonyms	CAY10554
Molecular Weight	260.35
Formula	C14H16N2OS
CAS No.	267654-00-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO:PBS (pH 7.2)(1:2): 0.3 mg/mL

DMF: 30 mg/mL

DMSO: 120 mg/mL (460.92 mM), Sonication is recommended.

Ethanol: 0.25 mg/mL

References and Literature

1. Kaźmierczak A, et al. A novel mechanism of non-Aβ component of Alzheimer's disease amyloid (NAC) neurotoxicity. Interplay between p53 protein and cyclin-dependent kinase 5 (Cdk5). Neurochem Int. 2011;58(2):206-214.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Bioactive Compound Library Anti-Breast Cancer Compound Library Anti-Pancreatic Cancer Compound Library Kinase Inhibitor Library Bioactive Compounds Library Max Anti-Cancer Compound Library

Related Products

Related compounds with same targets

Flavopiridol VX-11e CDK9-IN-29 Indoramin D5 TC11 RSS0680 GSK 3 Inhibitor IX Senexin A

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BML-259 267654-00-2 Cell Cycle/Checkpoint CDK protein CAY 10554 p53 CAY10554 death disease,neurotoxicity cell Inhibitor inhibit BML 259 Cyclin dependent kinase CAY-10554 Alzheimer's BML259 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.