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BML-259

Name: BML-259
Brand: TargetMol
SKU: T36964
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36964Cas No. 267654-00-2

Alias CAY10554

BML-259 is an inhibitor of CDK5 and CDK2 with IC50s of 64 and 98 nM, respectively. BML-259 can be used in studies about the treatment of cancer and neurodegenerative diseases.

BML-259

🥰Excellent

Purity: 99.84%

Catalog No. T36964Alias CAY10554Cas No. 267654-00-2

BML-259 is an inhibitor of CDK5 and CDK2 with IC50s of 64 and 98 nM, respectively. BML-259 can be used in studies about the treatment of cancer and neurodegenerative diseases.

Pack Size	Price	Availability
5 mg	$43	In Stock
10 mg	$77	In Stock
25 mg	$172	In Stock
50 mg	$293	In Stock
100 mg	$513	In Stock
500 mg	$1,090	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock

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Purity:99.84%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	BML-259 is an inhibitor of CDK5 and CDK2 with IC50s of 64 and 98 nM, respectively. BML-259 can be used in studies about the treatment of cancer and neurodegenerative diseases.
In vitro	BML-259 prevents a large population of cells from NAC-evoked cell death[1].
Synonyms	CAY10554

Chemical Properties

Molecular Weight	260.35
Formula	C₁₄H₁₆N₂OS
Cas No.	267654-00-2
Smiles	CC(C)c1cnc(NC(=O)Cc2ccccc2)s1
Relative Density.	no data available

Storage & Solubility Information

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO:PBS (pH 7.2)(1:2): 0.3 mg/mL (1.15 mM), Sonication is recommended. DMF: 30 mg/mL (115.23 mM), Sonication is recommended. DMSO: 120 mg/mL (460.92 mM), Sonication is recommended. Ethanol: 0.25 mg/mL (0.96 mM), Sonication is recommended.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc