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Minesapride

Name: Minesapride
Brand: TargetMol
SKU: T28043L
Price: 117 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28043LCas No. 1184662-54-1

Minesapride, a novel 5-hydroxytryptamine 4 (5-HT4) receptor partial agonist, is a potential gastrointestinal prokinetic agent for the treatment of irritable bowel syndrome with constipation.

Minesapride

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Purity: 99.9%

Catalog No. T28043LCas No. 1184662-54-1

Minesapride, a novel 5-hydroxytryptamine 4 (5-HT4) receptor partial agonist, is a potential gastrointestinal prokinetic agent for the treatment of irritable bowel syndrome with constipation.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$117	In Stock	In Stock
5 mg	$258	In Stock	In Stock
10 mg	$382	In Stock	In Stock
25 mg	$592	In Stock	In Stock
50 mg	$845	In Stock	In Stock
100 mg	$1,170	In Stock	In Stock
200 mg	$1,570	-	In Stock
1 mL x 10 mM (in DMSO)	$298	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.9%

ee:100%

Appearance:Solid

Color:White

Resource Download

COA CSFC HNMR LCMS

Product Introduction

Bioactivity

Description	Minesapride, a novel 5-hydroxytryptamine 4 (5-HT4) receptor partial agonist, is a potential gastrointestinal prokinetic agent for the treatment of irritable bowel syndrome with constipation.
In vivo	Minesapride (1, 4, 12, or 40 mg; once daily; 4 weeks) improved in Minesapride 40 mg group abdominal symptoms score at week 4. In a phase 2 trial of patients with IBS-C in Japan, minesapride increased stool frequency (measured by CSBMs), reduced abdominal and overall IBS-C symptoms, and was well tolerated.[1]

Chemical Properties

Molecular Weight	454.95
Formula	C₂₁H₃₁ClN₄O₅
Cas No.	1184662-54-1
Smiles	C(NC[C@H]1CN(CC2CCN(C(CO)=O)CC2)CCO1)(=O)C3=C(OC)C=C(N)C(Cl)=C3
Relative Density.	1.290 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (65.94 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1980 mL	10.9902 mL	21.9804 mL	109.9022 mL
5 mM	0.4396 mL	2.1980 mL	4.3961 mL	21.9804 mL
10 mM	0.2198 mL	1.0990 mL	2.1980 mL	10.9902 mL
20 mM	0.1099 mL	0.5495 mL	1.0990 mL	5.4951 mL
50 mM	0.0440 mL	0.2198 mL	0.4396 mL	2.1980 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc