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AMG-47a
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Catalog No. T7123Cas No. 882663-88-9
AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protein in cells.
AMG-47a
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Purity: 98%
Catalog No. T7123Cas No. 882663-88-9
AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protein in cells.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $38 | In Stock | In Stock | |
| 5 mg | $89 | In Stock | In Stock | |
| 10 mg | $155 | In Stock | In Stock | |
| 25 mg | $262 | In Stock | In Stock | |
| 50 mg | $389 | In Stock | In Stock | |
| 100 mg | $573 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $97 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98%
Appearance:Solid
Color:White
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Product Introduction
AMG-47a AI Summary
AMG-47a exhibits a variety of bioactivities and potent inhibitory effects on several kinases, including Lck, KDR, p38-alpha, Src, JNK1, JNK2, JNK3, Btk, and Yes1, with IC50 values in the nanomolar range. It also demonstrates notable inhibition of the NFkB signaling pathway (4726.9 nM) and exhibits cytotoxicity in a counterscreen for NFkB agonists and antagonists (20931.0 nM). Additionally, AMG-47a shows moderate potency in cell proliferation assays against the TMD8 cell line with caspase readouts at 8 and 16 hours (20931.0 nM and 2956.6 nM, respectively). It induces sensitization/mitigation effects in immunotoxin studies for HA22 and SS1P (6619.0 nM to 14818.0 nM) and demonstrates high potency in identifying gametocytocidal compounds (74266.1 nM). Furthermore, it inhibits T cell proliferation, IL2 secretion, and various cytokine productions in human and mouse models, and has moderate bioavailability, favorable protein binding properties, and pharmacokinetic parameters suitable for further development as a therapeutic agent targeting immune response pathways..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protein in cells. |
| Targets&IC50 | IL-2:21 nM (IC50), MLR:30 nM (IC50), JAK3:72 nM (IC50), VEGF2:1 nM (IC50), p38α:3 nM (IC50), Lck:0.2 nM (IC50) |
| Molecular Weight | 535.56 |
| Formula | C29H28F3N5O2 |
| Cas No. | 882663-88-9 |
| Smiles | Cc1ccc(cc1-c1ccc2nc(NCCN3CCOCC3)ncc2c1)C(=O)Nc1cccc(c1)C(F)(F)F |
| Relative Density. | 1.324 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 34 mg/mL (63.48 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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