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Mavorixafor trihydrochloride

Name: Mavorixafor trihydrochloride
Brand: TargetMol
SKU: T10296
Rating: 4.5 (1 reviews)

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Catalog No. T10296Cas No. 2309699-17-8

Alias AMD-070 trihydrochloride

Mavorixafor trihydrochloride is a selective and orally available CXCR4 antagonist (IC50: 13 nM against CXCR4 125I-SDF binding) and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs (IC50s: 1 and 9 nM).

Mavorixafor trihydrochloride

😃Good

Catalog No. T10296Alias AMD-070 trihydrochlorideCas No. 2309699-17-8

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$87	5 days	5 days
25 mg	$652	1-2 weeks	1-2 weeks
50 mg	$847	1-2 weeks	1-2 weeks
100 mg	$1,390	1-2 weeks	1-2 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Mavorixafor trihydrochloride is a selective and orally available CXCR4 antagonist (IC50: 13 nM against CXCR4 125I-SDF binding) and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs (IC50s: 1 and 9 nM).
Targets&IC50	HIV-1 (NL4.3 strain):9 nM (in PBMCs), HIV-1:26 nM (IC90, in PBMCs), HIV-1 (NL4.3 strain):1 nM (in MT-4 cells), HIV-1 (NL4.3 strain):3 nM (IC90, in MT-4 cells), [125I]-SDF-CXCR4:13 nM
In vitro	Mavorixafor (AMD-070) shows no effect on other chemokine receptors (CCR1, CCR2b, CCR4, CCR5, CXCR1, and CXCR2) [1]. Mavorixafor (6.6 μM) significantly suppresses the anchorage-dependent growth, the migration and matrigel invasion of the B88-SDF-1 cells [2].
In vivo	Mavorixafor, at a dosage of 2 mg/kg administered orally, substantially decreases the count of metastatic lung nodules in mice while concurrently reducing the expression of human Alu DNA, all without causing loss in body weight [2].
Synonyms	AMD-070 trihydrochloride

Chemical Properties

Molecular Weight	458.86
Formula	C₂₁H₃₀Cl₃N₅
Cas No.	2309699-17-8
Smiles	Cl.Cl.Cl.NCCCCN(Cc1nc2ccccc2[nH]1)[C@H]1CCCc2cccnc12
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 6 mg/mL (13.08 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1793 mL	10.8966 mL	21.7931 mL	108.9657 mL
5 mM	0.4359 mL	2.1793 mL	4.3586 mL	21.7931 mL
10 mM	0.2179 mL	1.0897 mL	2.1793 mL	10.8966 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc