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Anti-SCGN Antibody (3Y839) is a Mouse antibody targeting SCGN. Anti-SCGN Antibody (3Y839) can be used in ELISA,ELISA(Det).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
20 μL | $70 | 7-10 days | |
100 μL | $199 | 7-10 days |
Description | Anti-SCGN Antibody (3Y839) is a Mouse antibody targeting SCGN. Anti-SCGN Antibody (3Y839) can be used in ELISA,ELISA(Det). |
Alias | setagin, SEGN, secretagogin, EF-hand calcium binding protein, SECRET, DJ501N12.8, CALBL |
Ig Type | Monoclonal Mouse IgG1 |
Clone | 3Y839 |
Reactivity | Human |
Application | ELISA,ELISA(Det) |
Recommended Dose | ELISA: 1:1000-1:2000; ELISA(Det): 1:1000-1:10000 |
Antibody Type | Monoclonal |
Host Species | Mouse |
Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human SCGN / Secretagogin(rh SCGN / Secretagogin; Catalog #12411-H07E; NP_008929.2; Asp 2-Pro 276). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
Purification | Protein A |
Appearance | Liquid |
Formulation | 0.2 μm filtered solution in PBS |
Research Background | Secretagogin, also known as SCGN, is a secreted protein that is detectable in human serum after ischemic neuronal damage. It is a recently described calcium-binding protein. Secretagogin / SCGN is expressed at high levels in the pancreatic islets of Langerhans and to a much lesser extent in the gastrointestinal tract (stomach, small intestine and colon), the adrenal medulla and cortex and the thyroid C-cells. In the brain, the expression of Secretagogin / SCGN is restricted to distinct subtypes of neurons with highest expression in the molecular layer of the cerebellum (stellate and basket cells), in the anterior part of the pituitary gland, in the thalamus, in the hypothalamus and in a subgroup of neocortical neurons. Secretagogin / SCGN is widely expressed in prostatic adenocarcinoma as opposed to adenocarcinomas in other organs. The function of Secretagogin / SCGN is unknown, but it has been suggested in beta-cells to influence calcium-influx and has been observed downregulated in diabetes-prone BB rat islets exposed to cytokines. Secretagogin / SCGN is involved in the calcium metabolism of tumour cells and endothelial cells in a subset of neoplasms of the brain and its coverings. Secretagogin / SCGN is also a novel marker for neuroendocrine differentiation. |
Conjucates | Unconjugated |
Immunogen | Recombinant Human SCGN / Secretagogin Protein (TMPY-01875) |
Antigen Species | Human |
Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
Transport | Shipping with blue ice. |
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