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Anti-Phospho-Cyclin D1 (Thr286) Polyclonal Antibody
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Catalog No. TMAB-10562
Anti-Phospho-Cyclin D1 (Thr286) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Cyclin D1 (Thr286). Anti-Phospho-Cyclin D1 (Thr286) Polyclonal Antibody can be used in ICC/IF.
Anti-Phospho-Cyclin D1 (Thr286) Polyclonal Antibody
Anti-Phospho-Cyclin D1 (Thr286) Polyclonal Antibody
😃Good
Catalog No. TMAB-10562
Anti-Phospho-Cyclin D1 (Thr286) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Cyclin D1 (Thr286). Anti-Phospho-Cyclin D1 (Thr286) Polyclonal Antibody can be used in ICC/IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-Cyclin D1 (Thr286) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Cyclin D1 (Thr286). Anti-Phospho-Cyclin D1 (Thr286) Polyclonal Antibody can be used in ICC/IF. |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Dog,Cow,Sheep) |
| Application | |
| Recommended Dose | ICC/IF: 1:50-200 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Cytoplasm. Membrane. Note=CyclinD-CDK4 complexes accumulate at the nuclear membrane and are thentranslocated to the nucleus through interaction with KIP/CIP familymembers. |
| Construction | Hybridoma Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]. |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human Cyclin D1 around the phosphorylation site of Thr286 |
| Antigen Species | Human |
| Gene Name | CCND1 |
| Gene ID | |
| Protein Name | G1/S-specific cyclin-D1 |
| Uniprot ID | |
| Function | Regulatory component of the cyclin D1-CDK4 (DC) complexthat phosphorylates and inhibits members of the retinoblastoma (RB)protein family including RB1 and regulates the cell-cycle duringG(1)/S transition. Phosphorylation of RB1 allows dissociation ofthe transcription factor E2F from the RB/E2F complex and thesubsequent transcription of E2F target genes which are responsiblefor the progression through the G(1) phase. Hypophosphorylates RB1in early G(1) phase. Cyclin D-CDK4 complexes are major integratorsof various mitogenenic and antimitogenic signals. Also substratefor SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent mannerand repressing its transcriptional activity. Component of theternary complex, cyclin D1/CDK4/CDKN1B, required for nucleartranslocation and activity of the cyclin D-CDK4 complex. |
| Molecular Weight | Theoretical: 34 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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