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NLRP3-IN-41

Name: NLRP3-IN-41
Brand: TargetMol
SKU: T88711
Rating: 4.5 (1 reviews)

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Catalog No. T88711Cas No. 1209698-02-1

NLRP3-IN-41 administered at doses of 40 and 80 mg/kg through intragastric (i.g.) delivery over a span of 10 days, successfully alleviated the symptoms of colitis induced by DSS in both C57BL/6 and ICR mice.

NLRP3-IN-41

😃Good

Catalog No. T88711Cas No. 1209698-02-1

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,520	4-6 weeks	4-6 weeks
50 mg	$1,980	4-6 weeks	4-6 weeks
100 mg	$2,500	4-6 weeks	4-6 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	NLRP3-IN-41 administered at doses of 40 and 80 mg/kg through intragastric (i.g.) delivery over a span of 10 days, successfully alleviated the symptoms of colitis induced by DSS in both C57BL/6 and ICR mice.
In vitro	NLRP3-IN-41 (5-15 μM, 24 h) effectively inhibits the induction of IL-1β by LPS (100 ng/mL) and ATP (5 mM) in THP-M and also suppresses AIM2 and NLRC4 inflammasomes.
In vivo	NLRP3-IN-41 administered at doses of 40 and 80 mg/kg through intragastric (i.g.) delivery over a span of 10 days, successfully alleviated the symptoms of colitis induced by DSS in both C57BL/6 and ICR mice.

Chemical Properties

Molecular Weight	442.55
Formula	C₂₂H₂₂N₂O₄S₂
Cas No.	1209698-02-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc