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7-Amino-4-(trifluoromethyl)coumarin

🥰Excellent
Catalog No. TJS0341Cas No. 53518-15-3
Alias Coumarin 151, AFC

7-Amino-4-(trifluoromethyl)coumarin (Coumarin 151) is a 5-Hydroxytryptamine Receptor Subtype 1E (HTR1E) antagonist, a Galanin Receptor 2 (GALR2) antagonist, and a hydroxysteroid (17-beta) dehydrogenase 4 (HSD17B4) inhibitor with an activity value of 21 µM.

7-Amino-4-(trifluoromethyl)coumarin

7-Amino-4-(trifluoromethyl)coumarin

🥰Excellent
Purity: 97.84%
Catalog No. TJS0341Alias Coumarin 151, AFCCas No. 53518-15-3
7-Amino-4-(trifluoromethyl)coumarin (Coumarin 151) is a 5-Hydroxytryptamine Receptor Subtype 1E (HTR1E) antagonist, a Galanin Receptor 2 (GALR2) antagonist, and a hydroxysteroid (17-beta) dehydrogenase 4 (HSD17B4) inhibitor with an activity value of 21 µM.
Pack SizePriceAvailabilityQuantity
200 mg$30In Stock
500 mg$47In Stock
1 mL x 10 mM (in DMSO)$29In Stock
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Batch Information

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Purity:97.84%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
7-Amino-4-(trifluoromethyl)coumarin (Coumarin 151) is a 5-Hydroxytryptamine Receptor Subtype 1E (HTR1E) antagonist, a Galanin Receptor 2 (GALR2) antagonist, and a hydroxysteroid (17-beta) dehydrogenase 4 (HSD17B4) inhibitor with an activity value of 21 µM.
SynonymsCoumarin 151, AFC
Chemical Properties
Molecular Weight229.16
FormulaC10H6F3NO2
Cas No.53518-15-3
SmilesNC1=CC=C2C(OC(=O)C=C2C(F)(F)F)=C1
Relative Density.1.4096 g/cm3 (Estimated)
ColorYellow
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (218.19 mM), Sonication is recommended.
H2O: Insoluble
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.3638 mL21.8188 mL43.6376 mL218.1882 mL
5 mM0.8728 mL4.3638 mL8.7275 mL43.6376 mL
10 mM0.4364 mL2.1819 mL4.3638 mL21.8188 mL
20 mM0.2182 mL1.0909 mL2.1819 mL10.9094 mL
50 mM0.0873 mL0.4364 mL0.8728 mL4.3638 mL
100 mM0.0436 mL0.2182 mL0.4364 mL2.1819 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

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