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Bunaftide

Name: Bunaftide
Brand: TargetMol
SKU: T10634
Price: 167 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10634Cas No. 32421-46-8

Alias Meregon, Bunaphtide, Bunaftine

Bunaftide (Bunaphtid) has antiarrhythmic effects and inhibits aconitine-induced ventricular tachycardia.

Bunaftide

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Purity: 99.16%

Catalog No. T10634Alias Meregon, Bunaphtide, BunaftineCas No. 32421-46-8

Bunaftide (Bunaphtid) has antiarrhythmic effects and inhibits aconitine-induced ventricular tachycardia.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$167	-	In Stock
5 mg	$407	-	In Stock
10 mg	$541	-	In Stock
25 mg	$819	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.16%

Appearance:Oil

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Bunaftide (Bunaphtid) has antiarrhythmic effects and inhibits aconitine-induced ventricular tachycardia.
In vitro	Bunaftide (0.5-2.0 mM) causes contraction and rounding of the cells with loss of microvilli-like processes. 0.4 mM Bunaftide increases and 0.8-1.0 mM markedly decreases the percentage of mitotic cells, without accumulation of cells in any particular stage of mitosis.[1] Bunaftide (1, 5, and 10 mg/L) produces a concentration-dependent depression of the maximum rate of rising of the action potential in guinea pig papillary muscle preparations without affecting the resting membrane potential and the action potential amplitude. The action potential duration (APD50, APD90) is significantly prolonged by the treatment with 1 and 5 mg/L Bunaftide, while it is not changed by the treatment with 10 mg/L.[2]
Synonyms	Meregon, Bunaphtide, Bunaftine

Chemical Properties

Molecular Weight	326.48
Formula	C₂₁H₃₀N₂O
Cas No.	32421-46-8
Smiles	C(N(CCN(CC)CC)CCCC)(=O)C=1C2=C(C=CC1)C=CC=C2
Relative Density.	1.026g/cm3

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (183.78 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0630 mL	15.3149 mL	30.6297 mL	153.1487 mL
5 mM	0.6126 mL	3.0630 mL	6.1259 mL	30.6297 mL
10 mM	0.3063 mL	1.5315 mL	3.0630 mL	15.3149 mL
20 mM	0.1531 mL	0.7657 mL	1.5315 mL	7.6574 mL
50 mM	0.0613 mL	0.3063 mL	0.6126 mL	3.0630 mL
100 mM	0.0306 mL	0.1531 mL	0.3063 mL	1.5315 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc