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Emzadirib

Name: Emzadirib
Brand: TargetMol
SKU: T12682
Price: 158 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12682Cas No. 2301085-04-9

Alias RAD51-IN-2, CYT-0851

Emzadirib (RAD51-IN-2) is a potent inhibitor of RAD51, showing potential anticancer activity and useful for studying DNA damage repair.

Emzadirib

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Purity: 99.9%

Catalog No. T12682Alias RAD51-IN-2, CYT-0851Cas No. 2301085-04-9

Emzadirib (RAD51-IN-2) is a potent inhibitor of RAD51, showing potential anticancer activity and useful for studying DNA damage repair.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$158	-	In Stock
2 mg	$235	-	In Stock
5 mg	$396	-	In Stock
10 mg	$662	-	In Stock
25 mg	$1,060	-	In Stock
50 mg	$1,410	-	In Stock
1 mL x 10 mM (in DMSO)	$436	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.9%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Emzadirib (RAD51-IN-2) is a potent inhibitor of RAD51, showing potential anticancer activity and useful for studying DNA damage repair.
In vitro	The EC50 values in various cell lines with different expression levels of activation-induced cytidine deaminase (AICDA) indicate good activity in the Daudi, U-698-M, and CCRF-SB cancer cell lines[1].
Synonyms	RAD51-IN-2, CYT-0851

Chemical Properties

Molecular Weight	580.76
Formula	C₂₇H₄₀N₄O₆S₂
Cas No.	2301085-04-9
Smiles	CC(C)OC(=O)N[C@H]1CC[C@@H](CC1)c1ncc(s1)-c1ccc(NC(=O)OC(C)C)cc1S(=O)(=O)NC(C)(C)C
Relative Density.	1.27 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (137.75 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7219 mL	8.6094 mL	17.2188 mL	86.0941 mL
5 mM	0.3444 mL	1.7219 mL	3.4438 mL	17.2188 mL
10 mM	0.1722 mL	0.8609 mL	1.7219 mL	8.6094 mL
20 mM	0.0861 mL	0.4305 mL	0.8609 mL	4.3047 mL
50 mM	0.0344 mL	0.1722 mL	0.3444 mL	1.7219 mL
100 mM	0.0172 mL	0.0861 mL	0.1722 mL	0.8609 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc