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Emzadirib

Name: Emzadirib
Brand: TargetMol
SKU: T12682
Price: 115 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12682Cas No. 2301085-04-9

Alias RAD51-IN-2, CYT-0851

Emzadirib (RAD51-IN-2) is a potent inhibitor of RAD51, showing potential anticancer activity and useful for studying DNA damage repair.

Emzadirib

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Purity: 99.9%

Catalog No. T12682Alias RAD51-IN-2, CYT-0851Cas No. 2301085-04-9

Emzadirib (RAD51-IN-2) is a potent inhibitor of RAD51, showing potential anticancer activity and useful for studying DNA damage repair.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$115	-	In Stock
5 mg	$286	-	In Stock
10 mg	$392	-	In Stock
25 mg	$643	-	In Stock
50 mg	$977	-	In Stock
1 mL x 10 mM (in DMSO)	$436	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.9%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Emzadirib (RAD51-IN-2) is a potent inhibitor of RAD51, showing potential anticancer activity and useful for studying DNA damage repair.
In vitro	The EC50 values in various cell lines with different expression levels of activation-induced cytidine deaminase (AICDA) indicate good activity in the Daudi, U-698-M, and CCRF-SB cancer cell lines[1].
Synonyms	RAD51-IN-2, CYT-0851

Chemical Properties

Molecular Weight	580.76
Formula	C₂₇H₄₀N₄O₆S₂
Cas No.	2301085-04-9
Smiles	CC(C)OC(=O)N[C@H]1CC[C@@H](CC1)c1ncc(s1)-c1ccc(NC(=O)OC(C)C)cc1S(=O)(=O)NC(C)(C)C
Relative Density.	1.27 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (137.75 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7219 mL	8.6094 mL	17.2188 mL	86.0941 mL
5 mM	0.3444 mL	1.7219 mL	3.4438 mL	17.2188 mL
10 mM	0.1722 mL	0.8609 mL	1.7219 mL	8.6094 mL
20 mM	0.0861 mL	0.4305 mL	0.8609 mL	4.3047 mL
50 mM	0.0344 mL	0.1722 mL	0.3444 mL	1.7219 mL
100 mM	0.0172 mL	0.0861 mL	0.1722 mL	0.8609 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc