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Fezolinetant
🥰Excellent
Catalog No. T15278Cas No. 1629229-37-3
Alias ESN-364
Fezolinetant (ESN-364) is a neurokinin-3 receptor antagonist that is being investigated for menopausal hot flashes.
Fezolinetant
🥰Excellent
Purity: 99.7%
Catalog No. T15278Alias ESN-364Cas No. 1629229-37-3
Fezolinetant (ESN-364) is a neurokinin-3 receptor antagonist that is being investigated for menopausal hot flashes.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $73 | In Stock | |
| 5 mg | $152 | In Stock | |
| 10 mg | $243 | In Stock | |
| 25 mg | $488 | In Stock | |
| 50 mg | $787 | In Stock | |
| 100 mg | $1,180 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $167 | In Stock |
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Purity:99.7%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Fezolinetant (ESN-364) is a neurokinin-3 receptor antagonist that is being investigated for menopausal hot flashes. |
| In vivo | METHODS: Fezolinetant (ESN-364) (1 mg/kg, intravenously) was administered to ovariectomized ewes, and LH/FSH measurements or pharmacokinetic analysis were performed. RESULTS Fezolinetant reversibly inhibited the regular pulsatile secretion of LH in ovariectomized ewes; plasma FSH levels did not change during the experimental period. [1] METHODS: Fezolinetant (5 mg/kg, oral) was administered to castrated cynomolgus monkeys, and LH/FSH measurements or pharmacokinetic analysis were performed. RESULTS Fezolinetant decreased plasma LH, but not FSH, in castrated monkeys. [1] |
| Synonyms | ESN-364 |
| Molecular Weight | 358.39 |
| Formula | C16H15FN6OS |
| Cas No. | 1629229-37-3 |
| Smiles | C[C@H]1N(CCn2c1nnc2-c1nc(C)ns1)C(=O)c1ccc(F)cc1 |
| Relative Density. | 1.56 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (27.9 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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