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PKZ18
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Catalog No. T204863Cas No. 849658-87-3
Alias PKZ-18, PKZ 18
PKZ18 is an antibiotic that inhibits bacterial growth with minimum inhibitory concentrations of 32–64 μg/mL against most Gram-positive bacteria, acting by suppressing in vivo transcription and translation of glycyl-tRNA synthetase mRNA, selectively targeting stem I specifier loops in Gram-positive organisms, reducing T-box transcriptional read-through, disrupting codon–anticodon recognition required for tRNA binding, and demonstrating a mechanism that is refractory to conventional resistance development.
PKZ18
😃Good
Purity: 98.08%
Catalog No. T204863Alias PKZ-18, PKZ 18Cas No. 849658-87-3
PKZ18 is an antibiotic that inhibits bacterial growth with minimum inhibitory concentrations of 32–64 μg/mL against most Gram-positive bacteria, acting by suppressing in vivo transcription and translation of glycyl-tRNA synthetase mRNA, selectively targeting stem I specifier loops in Gram-positive organisms, reducing T-box transcriptional read-through, disrupting codon–anticodon recognition required for tRNA binding, and demonstrating a mechanism that is refractory to conventional resistance development.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $195 | - | In Stock | |
| 5 mg | $483 | - | In Stock | |
| 10 mg | $691 | - | In Stock | |
| 25 mg | $1,080 | - | In Stock | |
| 50 mg | $1,490 | - | In Stock | |
| 100 mg | $1,960 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.08%
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | PKZ18 is an antibiotic that inhibits bacterial growth with minimum inhibitory concentrations of 32–64 μg/mL against most Gram-positive bacteria, acting by suppressing in vivo transcription and translation of glycyl-tRNA synthetase mRNA, selectively targeting stem I specifier loops in Gram-positive organisms, reducing T-box transcriptional read-through, disrupting codon–anticodon recognition required for tRNA binding, and demonstrating a mechanism that is refractory to conventional resistance development. |
| In vitro | By stabilizing a specific terminator conformation in the T-box riboswitch, PKZ18 halted the transcription of essential genes such as glyQS and tyrS. PKZ18 demonstrated bacteriostatic activity against MRSA with an MIC of 32-64 μg/mL [1]. |
| Synonyms | PKZ-18, PKZ 18 |
| Molecular Weight | 398.52 |
| Formula | C22H26N2O3S |
| Cas No. | 849658-87-3 |
| Smiles | C(NC1=NC(=C(C)S1)C2=CC=C(C(C)C)C=C2)(=O)[C@@H]3[C@H](C(O)=O)[C@@]4(C[C@]3(CC4)[H])[H] |
| Color | White |
| Appearance | Solid |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyThe above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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