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G907

Name: G907
Brand: TargetMol
SKU: T11348
Rating: 4.5 (1 reviews)

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Catalog No. T11348Cas No. 2244035-16-1

G907 is a selective and potent antagonist of the small molecule ATP-binding cassette (ABC) transporter protein MsbA, with bactericidal activity, which traps MsbA in the inner lipopolysaccharide. G907 inhibits E. coli MsbA with an IC50 value of 18 nM.

G907

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Purity: 98.14%

Catalog No. T11348Cas No. 2244035-16-1

Pack Size	Price	Availability	Quantity
1 mg	$166	7-10 days

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Batch Information

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Purity:98.14%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	G907 is a selective and potent antagonist of the small molecule ATP-binding cassette (ABC) transporter protein MsbA, with bactericidal activity, which traps MsbA in the inner lipopolysaccharide. G907 inhibits E. coli MsbA with an IC50 value of 18 nM.
Targets&IC50	MsbA:18 nM
In vitro	G907 inhibits the activity of purified Escherichia coli MsbA with an IC50 value of 18 nM over a concentration range of 0.1 nM to 100 μM[1]. G907 exhibits allosteric inhibitory activity against MsbA[2]. At 100 nM, G907 completely inhibits the transport activity of biotin-PE in liposomes containing MsbA-WT protein[1].

Chemical Properties

Molecular Weight	433.93
Formula	C₂₆H₂₄ClNO₃
Cas No.	2244035-16-1
Smiles	CC(Oc1ccc2ncc(\C=C\C(O)=O)c(C3CC3)c2c1)c1c(Cl)cccc1C1CC1
Relative Density.	1.346 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (138.27 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3045 mL	11.5226 mL	23.0452 mL	115.2260 mL
5 mM	0.4609 mL	2.3045 mL	4.6090 mL	23.0452 mL
10 mM	0.2305 mL	1.1523 mL	2.3045 mL	11.5226 mL
20 mM	0.1152 mL	0.5761 mL	1.1523 mL	5.7613 mL
50 mM	0.0461 mL	0.2305 mL	0.4609 mL	2.3045 mL
100 mM	0.0230 mL	0.1152 mL	0.2305 mL	1.1523 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc