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BGB-102
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Catalog No. T10531Cas No. 807640-87-5
Alias JNJ-26483327
BGB-102 (JNJ-26483327) is a kinase inhibitor targeting FLT3 and YES1 and an antagonist targeting EGFR and VEGFR3, which may be useful in the study of macular degeneration and diseases associated with genetic disorders and malformations.
BGB-102
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Purity: 99.02%
Catalog No. T10531Alias JNJ-26483327Cas No. 807640-87-5
BGB-102 (JNJ-26483327) is a kinase inhibitor targeting FLT3 and YES1 and an antagonist targeting EGFR and VEGFR3, which may be useful in the study of macular degeneration and diseases associated with genetic disorders and malformations.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $328 | In Stock | In Stock | |
| 5 mg | $818 | In Stock | In Stock | |
| 10 mg | $1,080 | - | In Stock | |
| 25 mg | $1,630 | - | In Stock | |
| 50 mg | $2,190 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.02%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | BGB-102 (JNJ-26483327) is a kinase inhibitor targeting FLT3 and YES1 and an antagonist targeting EGFR and VEGFR3, which may be useful in the study of macular degeneration and diseases associated with genetic disorders and malformations. |
| Targets&IC50 | HER4:18 nM, EGFR:9.6 nM, HER2:18 nM, 18 nM:HER4 |
| In vitro | Herceptin was combined with pan HER inhibitor BGB-102 ( 1,5 or 10 μM ) to treat SKBR3 cells for 1 hour. The results showed that herceptin combined with BGB-102 could terminate the PKB feedback loop and had a synergistic effect in inhibiting the growth of xenograft tumors[1]. |
| In vivo | BT474 xenografts were treated with vehicle control, BGB-102 (75 mg/kg, orally twice daily), Herceptin (10 mg/kg；ip), or combination therapy of BGB-102 and Herceptin for 21 days, followed by observation for 120 days. The results indicated that the combination therapy of Herceptin with BGB-102 delayed the growth of BT474 xenograft tumors[1]. |
| Synonyms | JNJ-26483327 |
| Molecular Weight | 457.36 |
| Formula | C22H25BrN4O2 |
| Cas No. | 807640-87-5 |
| Smiles | BrC1=CC=C2C(=C1)NC=3N=CN=C4C=C(OC)C(OCCCCCN(C)C2)=CC43 |
| Relative Density. | 1.310 g/cm3 (Predicted) |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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