Shopping Cart

Your shopping cart is currently empty

BPDBA

Name: BPDBA
Brand: TargetMol
SKU: T26891
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T26891Cas No. 312281-74-6

BPDBA is an effective, selective, and non-competitive inhibitor of the betaine/GABA transporter (BGT-1), displaying inhibitory activity against human BGT-1 and mouse GAT2, with IC50 values of 20 μM and 35 μM, respectively.

BPDBA

Copy Product Info

😃Good

Purity: 99.95%

Catalog No. T26891Cas No. 312281-74-6

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$37	In Stock	In Stock
25 mg	$78	In Stock	In Stock
50 mg	$125	In Stock	In Stock
100 mg	$201	In Stock	In Stock
500 mg	$465	-	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.95%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

BPDBA AI Summary

BPDBA exhibits inhibition of TGF-b with a potency of 2818.4 nM and human tyrosyl-DNA phosphodiesterase 1 (TDP1) with a potency of 20596.2 nM. It also demonstrates inhibitory activity against various GABA transporters, including human BGT1, GAT1, GAT2, GAT3, and mouse GAT1, with IC50 values ranging from 13489.63 nM to 32000.0 nM. Furthermore, the solubility of BPDBA in pH 7.4 phosphate buffer after 24 hours is 40.0 μg/mL..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	BPDBA is an effective, selective, and non-competitive inhibitor of the betaine/GABA transporter (BGT-1), displaying inhibitory activity against human BGT-1 and mouse GAT2, with IC50 values of 20 μM and 35 μM, respectively.
Targets&IC50	GAT-2 (mice):35 μM, BGT1 (human):20 μM

Chemical Properties

Molecular Weight	363.28
Formula	C₁₉H₂₀Cl₂N₂O
Cas No.	312281-74-6
Smiles	C(N1CCC(NC(=O)C2=C(Cl)C=C(Cl)C=C2)CC1)C3=CC=CC=C3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (75.7 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7527 mL	13.7635 mL	27.5270 mL	137.6349 mL
5 mM	0.5505 mL	2.7527 mL	5.5054 mL	27.5270 mL
10 mM	0.2753 mL	1.3763 mL	2.7527 mL	13.7635 mL
20 mM	0.1376 mL	0.6882 mL	1.3763 mL	6.8817 mL
50 mM	0.0551 mL	0.2753 mL	0.5505 mL	2.7527 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc