GITR/TNFRSF18 Protein, Mouse, Recombinant (mFc)

Name: GITR/TNFRSF18 Protein, Mouse, Recombinant (mFc)
Brand: TargetMol
SKU: TMPY-05253
Rating: 4.5 (1 reviews)

(Synonyms: tumor necrosis factor receptor superfamily, member 18, Gitr, AITR) Copy Product Info

Synonyms: tumor necrosis factor receptor superfamily, member 18, Gitr, AITR

Catalog No. TMPY-05253 Copy Product Info

GITR/TNFRSF18 Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 41 kDa and the accession number is O35714-1.

Pack Size	Price	USA Stock	Global Stock
5 µg	$58	7-10 days	7-10 days
10 µg	$93	7-10 days	7-10 days
20 µg	$152	7-10 days	7-10 days
50 µg	$298	7-10 days	7-10 days
100 µg	$577	7-10 days	7-10 days
200 µg	$858	7-10 days	7-10 days
500 µg	$1,850	7-10 days	7-10 days
1 mg	$3,790	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	GITR/TNFRSF18 Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 41 kDa and the accession number is O35714-1.
Species	Mouse
Expression System	HEK293 Cells
Tag	C-mFc
Accession Number	O35714-1
Construction	A DNA sequence encoding the mouse TNFRSF18 (NP_033426.1) (Met1-His153) was expressed with the Fc region of mouse IgG1 at the C-terminus. Predicted N terminal: Gln 20
Protein Purity	> 95 % as determined by SDS-PAGE.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	tumor necrosis factor receptor superfamily, member 18, Gitr, AITR
Research Background	GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint TargetsImmunotherapyTargeted Therapy

Chemical Properties

Molecular Weight

41 kDa (predicted)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.