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KCNQ2/3 activator-1

Name: KCNQ2/3 activator-1
Brand: TargetMol
SKU: T9400
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9400Cas No. 1009344-33-5

KCNQ2/3 activator-1 is a Kv7.2/Kv7.3 (KCNQ2/3) potassium channel activator, details of which are from Compound A of Patent WO2021113757A1.

KCNQ2/3 activator-1

🥰Excellent

Purity: 99.47%

Catalog No. T9400Cas No. 1009344-33-5

KCNQ2/3 activator-1 is a Kv7.2/Kv7.3 (KCNQ2/3) potassium channel activator, details of which are from Compound A of Patent WO2021113757A1.

Pack Size	Price	Availability
2 mg	$34	In Stock
5 mg	$56	In Stock
10 mg	$86	In Stock
25 mg	$155	In Stock
50 mg	$248	In Stock
100 mg	$392	In Stock
500 mg	$987	In Stock
1 mL x 10 mM (in DMSO)	$62	In Stock

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Batch Information

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Purity:99.47%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

KCNQ2/3 activator-1 is a Kv7.2/Kv7.3 (KCNQ2/3) potassium channel activator, details of which are from Compound A of Patent WO2021113757A1.

Chemical Properties

Molecular Weight	368.49
Formula	C₂₃H₂₉FN₂O
Cas No.	1009344-33-5
Smiles	Cc1cc(cc(C)c1NC(=O)CC(C)(C)C)N1CCc2cc(F)ccc2C1
Relative Density.	1.125 g/cm3 at 20℃

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (122.12 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7138 mL	13.5689 mL	27.1378 mL	135.6889 mL
5 mM	0.5428 mL	2.7138 mL	5.4276 mL	27.1378 mL
10 mM	0.2714 mL	1.3569 mL	2.7138 mL	13.5689 mL
20 mM	0.1357 mL	0.6784 mL	1.3569 mL	6.7844 mL
50 mM	0.0543 mL	0.2714 mL	0.5428 mL	2.7138 mL
100 mM	0.0271 mL	0.1357 mL	0.2714 mL	1.3569 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc