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Glucosylsphingosine

Name: Glucosylsphingosine
Brand: TargetMol
SKU: T78493
Rating: 4.5 (1 reviews)

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Catalog No. T78493Cas No. 52050-17-6

Alias Lyso-Gb1, Glucosyl-C18-sphingosine, Glucopsychosine, 1-β-D-Glucosylsphingosine

Glucosylsphingosine (Lyso-Gb1) is a naturally occurring glycosyl ceramide, a metabolite of GBA (acid β-glucosidase), involved in cellular recognition, signaling, and intercellular interactions.Glucopsychosine accumulates in certain neurodegenerative diseases (e.g., Gaucher disease), disrupts lysosomal function through activation of mammalian target of rapamycin complex 1 (mTORC1), and is a noncompetitive inhibitor of glucocerebrosidase.

Glucosylsphingosine

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Catalog No. T78493Alias Lyso-Gb1, Glucosyl-C18-sphingosine, Glucopsychosine, 1-β-D-GlucosylsphingosineCas No. 52050-17-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$495	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Glucosylsphingosine (Lyso-Gb1) is a naturally occurring glycosyl ceramide, a metabolite of GBA (acid β-glucosidase), involved in cellular recognition, signaling, and intercellular interactions.Glucopsychosine accumulates in certain neurodegenerative diseases (e.g., Gaucher disease), disrupts lysosomal function through activation of mammalian target of rapamycin complex 1 (mTORC1), and is a noncompetitive inhibitor of glucocerebrosidase.
In vitro	Methods: MCF7 cells were treated with glucosylsphingosine (20-45 μM, 48 hours), and cell death was determined by PI and Hoechst-33342 staining. Results: Glucosylsphingosine killed MCF7 cells independently of apoptosis, ferroptosis, and necroptosis, and induced cell death in a dose-dependent manner, with an LC50 of 33 μM.[4]
In vivo	Methods: Adult male C57BL/6JRj mice were treated with glucosylsphingosine (10 mg/kg, subcutaneous injection, daily, for 12 consecutive weeks) and the inflammatory changes in the mice were observed. Results: Glucosylsphingosine accumulated in peripheral tissues and induced hematological symptoms in mice, such as decreased hemoglobin and hematocrit, increased spleen weight, and mild inflammatory tissue reactions, indicating that it induced visceral inflammatory reactions in mice. [6]
Synonyms	Lyso-Gb1, Glucosyl-C18-sphingosine, Glucopsychosine, 1-β-D-Glucosylsphingosine

Chemical Properties

Molecular Weight	461.63
Formula	C₂₄H₄₇NO₇
Cas No.	52050-17-6
Smiles	O(C[C@@H]([C@@H](/C=C/CCCCCCCCCCCCC)O)N)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 100 mg/mL (216.62 mM), Sonication is recommended.

DMSO: 80 mg/mL (173.3 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (7.15 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.1662 mL	10.8312 mL	21.6624 mL	108.3119 mL
5 mM	0.4332 mL	2.1662 mL	4.3325 mL	21.6624 mL
10 mM	0.2166 mL	1.0831 mL	2.1662 mL	10.8312 mL
20 mM	0.1083 mL	0.5416 mL	1.0831 mL	5.4156 mL
50 mM	0.0433 mL	0.2166 mL	0.4332 mL	2.1662 mL
100 mM	0.0217 mL	0.1083 mL	0.2166 mL	1.0831 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc