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Neurotensin

Name: Neurotensin
Brand: TargetMol
SKU: TP1310
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TP1310Cas No. 39379-15-2

Neurotensin is a 13 amino acid neuropeptide that is implicated in the regulation of luteinizing hormone and prolactin release and has significant interaction with the dopaminergic system.

Neurotensin

🥰Excellent

Catalog No. TP1310Cas No. 39379-15-2

Neurotensin is a 13 amino acid neuropeptide that is implicated in the regulation of luteinizing hormone and prolactin release and has significant interaction with the dopaminergic system.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$52	In Stock	In Stock
2 mg	$80	In Stock	In Stock
5 mg	$162	In Stock	In Stock
10 mg	$228	In Stock	In Stock
25 mg	$458	In Stock	In Stock
50 mg	$659	In Stock	In Stock
100 mg	$925	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:>99.99%

Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description

Neurotensin is a 13 amino acid neuropeptide that is implicated in the regulation of luteinizing hormone and prolactin release and has significant interaction with the dopaminergic system.

In vitro

Neurotensin induces the expression of inflammatory markers (MIP-2, MCP-1, IL-1β, TNFα) in murine microglial cells and promotes IL-8 secretion in colon epithelial cells harboring the NTR, a high-affinity receptor belonging to the GPCR family, prevalent in many pancreatic and colorectal cancers. This suggests Neurotensin's potential endocrine role in tumor growth. Acting through NTR1, it activates several signal transduction pathways, including intracellular calcium levels, MAPKs (ERK, JNK), and PKC isoforms. In HCT116 cancer cells, Neurotensin dramatically enhances migration approximately threefold, an effect inhibited by Curcumin pretreatment. Additionally, Neurotensin's activation of the MEK/ERK pathway and subsequent upregulation of AP-1 transcription factors underscore its contribution to cell proliferation.

Chemical Properties

Molecular Weight	1672.92
Formula	C₇₈H₁₂₁N₂₁O₂₀
Cas No.	39379-15-2
Smiles	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]5CCC(=O)N5)C(=O)N[C@@H](CC(C)C)C(O)=O
Relative Density.	1.46g/cm3
Sequence	Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu
Sequence Short	Pyr-LYENKPRRPYIL

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 36.43 mg/mL (21.78 mM), Sonication is recommended.

DMSO: 10 mM, Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	0.5978 mL	2.9888 mL	5.9776 mL	29.8879 mL
5 mM	0.1196 mL	0.5978 mL	1.1955 mL	5.9776 mL
10 mM	0.0598 mL	0.2989 mL	0.5978 mL	2.9888 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.0299 mL	0.1494 mL	0.2989 mL	1.4944 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc