Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Manganese(salen) chloride (EUK-8) (EUK-8) is a superoxide dismutase and catalase mimetic. Manganese(salen) chloride (EUK-8) is an antioxidant with oxyradical scavenging properties. Manganese(salen) chloride ameliorates acute lung injury in endotoxemic swine.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 39.00 | |
25 mg | In stock | $ 62.00 | |
50 mg | In stock | $ 91.00 | |
100 mg | In stock | $ 133.00 | |
200 mg | In stock | $ 197.00 | |
500 mg | In stock | $ 333.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 43.00 |
Description | Manganese(salen) chloride (EUK-8) (EUK-8) is a superoxide dismutase and catalase mimetic. Manganese(salen) chloride (EUK-8) is an antioxidant with oxyradical scavenging properties. Manganese(salen) chloride ameliorates acute lung injury in endotoxemic swine. |
In vitro | Manganese(salen) chloride (25 μM; 24-72 h) protects organotypic hippocampal slices from β-AP-induced neurotoxicity that also completely blocks β-AP-induced free radical accumulation and lipid peroxidation [2]. |
In vivo | Manganese(salen) chloride (25 mg/kg; i.p. 3 times a week for 4 weeks) reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant [3] . Animal Model: Wild-type (WT) and harlequin (Hq) B6CBA male and female mice [3] Dosage: 25 mg/kg/day Administration: I.p. 3 times a week for 4 weeks Result: Prevented myocardial oxidant damage provoked by biomechanical stress. Improved survival following biomechanical stress. Prevented functional and geometrical deterioration in response to pressure overload. Attenuated necrotic and apoptotic cell death, and attenuated cardiac hypertrophy and fibrosis. Furthermore, because antioxidant treatment protected both the oxidative stress-prone Hq mouse model and WT mice against pressure overload-induced maladaptive left ventricular remodeling and cardiac decompensation, it may be useful as a novel therapeutic tool in the treatment of human heart failure. |
Synonyms | EUK-8 |
Molecular Weight | 356.69 |
Formula | C16H14ClMnN2O2 |
CAS No. | 53177-12-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 8.33 mg/mL (23.35 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Manganese(salen) chloride 53177-12-1 Others Manganese(salen) inhibit dismutase catalase oxyradical mimetic Manganese(salen) Chloride Inhibitor antioxidant superoxide EUK-8 Reactive Oxygen Species scavenging EUK8 EUK 8 inhibitor